IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes

Jenny Hsieh, James B. Aimone, Brian K. Kaspar, Tomoko Kuwabara, Kinichi Nakashima, Fred H. Gage

研究成果: Contribution to journalArticle査読

261 被引用数 (Scopus)

抄録

Adult multipotent neural progenitor cells can differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian central nervous system, but the molecular mechanisms that control their differentiation are not yet well understood. Insulin-like growth factor I (IGF-I) can promote the differentiation of cells already committed to an oligodendroglial lineage during development. However, it is unclear whether IGF-I affects multipotent neural progenitor cells. Here, we show that IGF-I stimulates the differentiation of multipotent adult rat hippocampus-derived neural progenitor cells into oligodendrocytes. Modeling analysis indicates that the actions of IGF-I are instructive. Oligodendrocyte differentiation by IGF-I appears to be mediated through an inhibition of bone morphogenetic protein signaling. Furthermore, overexpression of IGF-I in the hippocampus leads to an increase in oligodendrocyte markers. These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage.

本文言語英語
ページ(範囲)111-122
ページ数12
ジャーナルJournal of Cell Biology
164
1
DOI
出版ステータス出版済み - 1 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 細胞生物学

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