IL-17 production by γδ T cells is important for the antitumor effect of Mycobacterium bovis bacillus Calmette-Guérin treatment against bladder cancer

ario takeuchi, Takashi Dejima, Hisakata Yamada, Kensuke Shibata, Risa Nakamura, Masatoshi Eto, Tatsuya Nakatani, Seiji Naito, Yasunobu Yoshikai

研究成果: ジャーナルへの寄稿記事

51 引用 (Scopus)

抄録

Intravesical inoculation of Mycobacterium bovis bacillus Calmette-Guérin (BCG) has been used for the treatment of bladder cancer. Recent studies implied the requirement of neutrophil infiltration for the antitumor effect. In this study, we found that IL-17 was produced in the bladder after BCG treatment, preceding the infiltration of neutrophils. Neutrophils in the bladder after BCG treatment were reduced in IL-17-deficient mice, in which BCG-induced antitumor effect against intravesically inoculated bladder cancer was abolished. Notably, the level of IL-17 production and the number of neutrophils in BCG-treated bladder was reduced in γδ T-cell-deficient mice but not in CD4-depleted mice. Survival of bladder cancer-inoculated γδ T-cell-deficient mice was not improved by BCG treatment. These results suggest that IL-17-producing γδ T cells play a key role in the BCG-induced recruitment of neutrophils to the bladder, which is essential for the antitumor activity against bladder cancer.

元の言語英語
ページ(範囲)246-251
ページ数6
ジャーナルEuropean Journal of Immunology
41
発行部数1
DOI
出版物ステータス出版済み - 1 1 2011

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Interleukin-17
Mycobacterium bovis
Urinary Bladder Neoplasms
Bacillus
T-Lymphocytes
Neutrophil Infiltration
Urinary Bladder
Neutrophils

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

これを引用

IL-17 production by γδ T cells is important for the antitumor effect of Mycobacterium bovis bacillus Calmette-Guérin treatment against bladder cancer. / takeuchi, ario; Dejima, Takashi; Yamada, Hisakata; Shibata, Kensuke; Nakamura, Risa; Eto, Masatoshi; Nakatani, Tatsuya; Naito, Seiji; Yoshikai, Yasunobu.

:: European Journal of Immunology, 巻 41, 番号 1, 01.01.2011, p. 246-251.

研究成果: ジャーナルへの寄稿記事

takeuchi, ario ; Dejima, Takashi ; Yamada, Hisakata ; Shibata, Kensuke ; Nakamura, Risa ; Eto, Masatoshi ; Nakatani, Tatsuya ; Naito, Seiji ; Yoshikai, Yasunobu. / IL-17 production by γδ T cells is important for the antitumor effect of Mycobacterium bovis bacillus Calmette-Guérin treatment against bladder cancer. :: European Journal of Immunology. 2011 ; 巻 41, 番号 1. pp. 246-251.
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abstract = "Intravesical inoculation of Mycobacterium bovis bacillus Calmette-Gu{\'e}rin (BCG) has been used for the treatment of bladder cancer. Recent studies implied the requirement of neutrophil infiltration for the antitumor effect. In this study, we found that IL-17 was produced in the bladder after BCG treatment, preceding the infiltration of neutrophils. Neutrophils in the bladder after BCG treatment were reduced in IL-17-deficient mice, in which BCG-induced antitumor effect against intravesically inoculated bladder cancer was abolished. Notably, the level of IL-17 production and the number of neutrophils in BCG-treated bladder was reduced in γδ T-cell-deficient mice but not in CD4-depleted mice. Survival of bladder cancer-inoculated γδ T-cell-deficient mice was not improved by BCG treatment. These results suggest that IL-17-producing γδ T cells play a key role in the BCG-induced recruitment of neutrophils to the bladder, which is essential for the antitumor activity against bladder cancer.",
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AU - Shibata, Kensuke

AU - Nakamura, Risa

AU - Eto, Masatoshi

AU - Nakatani, Tatsuya

AU - Naito, Seiji

AU - Yoshikai, Yasunobu

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