IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation

Yoon Hee Kim; Yu Ninomiya; Shuya Yamashita; Motofumi Kumazoe; Yuhui Huang; Kanami Nakahara; Yeong Seon Won; Motoki Murata; Yoshinori Fujimura; Koji Yamada; Hirofumi Tachibana

doi:10.1016/j.bbrc.2014.06.069

IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation

Yoon Hee Kim, Yu Ninomiya, Shuya Yamashita, Motofumi Kumazoe, Yuhui Huang, Kanami Nakahara, Yeong Seon Won, Motoki Murata, Yoshinori Fujimura, Koji Yamada, Hirofumi Tachibana

食料化学工学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

8 被引用数 (Scopus)

抄録

Strictinin has been shown to suppress interleukin (IL)-4-induced signal transducer and activator of transcription (STAT)-6 phosphorylation, which is a critical event for IgE class switching. However, it is unclear how strictinin inhibits STAT6 activation. Strictinin inhibited STAT6 phosphorylation by suppressing IL-4 receptor α (IL-4Rα) activation. Strictinin was bound to the cell surface and only localized in non-lipid raft fraction of the cells where IL-4Rα was also located. In addition, strictinin directly bound to IL-4Rα and inhibited binding of IL-4 to IL-4Rα. These results suggest that IL-4Rα locating in non-lipid raft region is a target molecule for strictinin in inhibiting STAT6 activation.

本文言語	英語
ページ（範囲）	824-830
ページ数	7
ジャーナル	Biochemical and Biophysical Research Communications
巻	450
号	1
DOI	https://doi.org/10.1016/j.bbrc.2014.06.069
出版ステータス	出版済み - 7月 18 2014

!!!All Science Journal Classification (ASJC) codes

生物理学
生化学
分子生物学
細胞生物学

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10.1016/j.bbrc.2014.06.069

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Kim, Y. H., Ninomiya, Y., Yamashita, S., Kumazoe, M., Huang, Y., Nakahara, K., Won, Y. S., Murata, M., Fujimura, Y., Yamada, K., & Tachibana, H. (2014). IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation. Biochemical and Biophysical Research Communications, 450(1), 824-830. https://doi.org/10.1016/j.bbrc.2014.06.069

@article{b16c094a1a8c46eea59f6ffe2ac33b64,

title = "IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation",

abstract = "Strictinin has been shown to suppress interleukin (IL)-4-induced signal transducer and activator of transcription (STAT)-6 phosphorylation, which is a critical event for IgE class switching. However, it is unclear how strictinin inhibits STAT6 activation. Strictinin inhibited STAT6 phosphorylation by suppressing IL-4 receptor α (IL-4Rα) activation. Strictinin was bound to the cell surface and only localized in non-lipid raft fraction of the cells where IL-4Rα was also located. In addition, strictinin directly bound to IL-4Rα and inhibited binding of IL-4 to IL-4Rα. These results suggest that IL-4Rα locating in non-lipid raft region is a target molecule for strictinin in inhibiting STAT6 activation.",

author = "Kim, {Yoon Hee} and Yu Ninomiya and Shuya Yamashita and Motofumi Kumazoe and Yuhui Huang and Kanami Nakahara and Won, {Yeong Seon} and Motoki Murata and Yoshinori Fujimura and Koji Yamada and Hirofumi Tachibana",

note = "Funding Information: This work was supported by Grants for Project Research (Development of Fundamental Technology for Analysis and Evaluation of Functional Agricultural Products and Functional Foods), in part by JSPS KAKENHI (Grants Number 22228002 ) and a Grant-in-Aid for JSPS Fellows ( JAG5002691 ). We would like to thank Kazuko Nakayama and Yusuke Hasegawa for technical assistance. ",

year = "2014",

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doi = "10.1016/j.bbrc.2014.06.069",

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AU - Kim, Yoon Hee

AU - Ninomiya, Yu

AU - Yamashita, Shuya

AU - Kumazoe, Motofumi

AU - Huang, Yuhui

AU - Nakahara, Kanami

AU - Won, Yeong Seon

AU - Murata, Motoki

AU - Fujimura, Yoshinori

AU - Yamada, Koji

AU - Tachibana, Hirofumi

N1 - Funding Information: This work was supported by Grants for Project Research (Development of Fundamental Technology for Analysis and Evaluation of Functional Agricultural Products and Functional Foods), in part by JSPS KAKENHI (Grants Number 22228002 ) and a Grant-in-Aid for JSPS Fellows ( JAG5002691 ). We would like to thank Kazuko Nakayama and Yusuke Hasegawa for technical assistance.

PY - 2014/7/18

Y1 - 2014/7/18

N2 - Strictinin has been shown to suppress interleukin (IL)-4-induced signal transducer and activator of transcription (STAT)-6 phosphorylation, which is a critical event for IgE class switching. However, it is unclear how strictinin inhibits STAT6 activation. Strictinin inhibited STAT6 phosphorylation by suppressing IL-4 receptor α (IL-4Rα) activation. Strictinin was bound to the cell surface and only localized in non-lipid raft fraction of the cells where IL-4Rα was also located. In addition, strictinin directly bound to IL-4Rα and inhibited binding of IL-4 to IL-4Rα. These results suggest that IL-4Rα locating in non-lipid raft region is a target molecule for strictinin in inhibiting STAT6 activation.

AB - Strictinin has been shown to suppress interleukin (IL)-4-induced signal transducer and activator of transcription (STAT)-6 phosphorylation, which is a critical event for IgE class switching. However, it is unclear how strictinin inhibits STAT6 activation. Strictinin inhibited STAT6 phosphorylation by suppressing IL-4 receptor α (IL-4Rα) activation. Strictinin was bound to the cell surface and only localized in non-lipid raft fraction of the cells where IL-4Rα was also located. In addition, strictinin directly bound to IL-4Rα and inhibited binding of IL-4 to IL-4Rα. These results suggest that IL-4Rα locating in non-lipid raft region is a target molecule for strictinin in inhibiting STAT6 activation.

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IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation

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!!!All Science Journal Classification (ASJC) codes

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