IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation

Yoon Hee Kim, Yu Ninomiya, Shuya Yamashita, Motofumi Kumazoe, Yuhui Huang, Kanami Nakahara, Yeong Seon Won, Motoki Murata, Yoshinori Fujimura, Koji Yamada, Hirofumi Tachibana

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Strictinin has been shown to suppress interleukin (IL)-4-induced signal transducer and activator of transcription (STAT)-6 phosphorylation, which is a critical event for IgE class switching. However, it is unclear how strictinin inhibits STAT6 activation. Strictinin inhibited STAT6 phosphorylation by suppressing IL-4 receptor α (IL-4Rα) activation. Strictinin was bound to the cell surface and only localized in non-lipid raft fraction of the cells where IL-4Rα was also located. In addition, strictinin directly bound to IL-4Rα and inhibited binding of IL-4 to IL-4Rα. These results suggest that IL-4Rα locating in non-lipid raft region is a target molecule for strictinin in inhibiting STAT6 activation.

本文言語英語
ページ(範囲)824-830
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
450
1
DOI
出版ステータス出版済み - 7 18 2014

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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