IL-6 receptor is a possible target against growth of metastasized lung tumor cells in the brain

Mami Noda, Yukiko Yamakawa, Naoya Matsunaga, Satoko Naoe, Taishi Jodoi, Megumi Yamafuji, Nozomi Akimoto, Norihiro Teramoto, Kyota Fujita, Shigehiro Ohdo, Haruo Iguchi

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)

抄録

In the animal model of brain metastasis using human lung squamous cell carcinoma-derived cells (HARA-B) inoculated into the left ventricle of the heart of nude mice, metastasized tumor cells and brain resident cells interact with each other. Among them, tumor cells and astrocytes have been reported to stimulate each other, releasing soluble factors from both sides, subsequently promoting tumor growth significantly. Among the receptors for soluble factors released from astrocytes, only IL-6 receptor (IL-6R) on tumor cells was up-regulated during the activation with astrocytes. Application of monoclonal antibody against human IL-6R (tocilizumab) to the activated HARA-B cells, the growth of HARA-B cells stimulated by the conditioned medium of HARA-B/astrocytes was significantly inhibited. Injecting tocilizumab to animal models of brain metastasis starting at three weeks of inoculation of HARA-B cells, two times a week for three weeks, significantly inhibited the size of the metastasized tumor foci. The up-regulated expression of IL-6R on metastasized lung tumor cells was also observed in the tissue from postmortem patients. These results suggest that IL-6R on metastasized lung tumor cells would be a therapeutic target to inhibit the growth of the metastasized lung tumor cells in the brain.

本文言語英語
ページ(範囲)515-526
ページ数12
ジャーナルInternational journal of molecular sciences
14
1
DOI
出版ステータス出版済み - 1月 2013

!!!All Science Journal Classification (ASJC) codes

  • 触媒
  • 分子生物学
  • 分光学
  • コンピュータ サイエンスの応用
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

フィンガープリント

「IL-6 receptor is a possible target against growth of metastasized lung tumor cells in the brain」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル