Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension

Yoshitaka Hirooka, Takuya Kishi, Koji Sakai, Akira Takeshita, Kenji Sunagawa

    研究成果: Contribution to journalReview article査読

    91 被引用数 (Scopus)

    抄録

    Nitric oxide (NO) and reactive oxygen species (ROS) play important roles in blood pressure regulation via the modulation of the autonomic nervous system, particularly in the central nervous system (CNS). In general, accumulating evidence suggests that NO inhibits, but ROS activates, the sympathetic nervous system. NO and ROS, however, interact with each other. Our consecutive studies and those of others strongly indicate that an imbalance between NO bioavailability and ROS generation in the CNS, including the brain stem, activates the sympathetic nervous system, and this mechanism is involved in the pathogenesis of neurogenic aspects of hypertension. In this review, we focus on the role of NO and ROS in the regulation of the sympathetic nervous system within the brain stem and subsequent cardiovascular control. Multiple mechanisms are proposed, including modulation of neurotransmitter release, inhibition of receptors, and alterations of intracellular signaling pathways. Together, the evidence indicates that an imbalance of NO and ROS in the CNS plays a pivotal role in the pathogenesis of hypertension.

    本文言語英語
    ページ(範囲)R818-R826
    ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    300
    4
    DOI
    出版ステータス出版済み - 4 2011

    All Science Journal Classification (ASJC) codes

    • 生理学
    • 生理学(医学)

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