Immune suppression gene on HLA-Bw54-DR4-DRw53 haplotype controls nonresponsiveness in humans to hepatitis B surface antigen via CD8+ suppressor T cells

Hiroshi Watanabe, Sho Matsushita, Nobuhiro Kamikawaji, Kenji Hirayama, Makoto Okumura, Takehiko Sasazuki

研究成果: ジャーナルへの寄稿記事

65 引用 (Scopus)

抜粋

The development of antiviral vaccines has been accelerated using monoclonal antibody and/or recombinant DNA techniques, the objective being to prevent grave viral infectious diseases, such as acquired immunodeficiency syndrome (AIDS), adult T-cell leukemia (ATL), and hepatitis B virus (HBV)-associated liver diseases. Certain proportions of individuals in the human population do not have any appreciable immune response to foreign antigens, either in cases of natural exposure or a planned immunization. Here we report that in the nonresponders to HB vaccine, there is an HLA-linked immune suppression gene for hepatitis B surface antigen (Is-HBsAg) controlling the nonresponsiveness to HBsAg through HBsAg-specific suppressor T cells. The Is-HBsAg is in strong linkage disequilibrium with the HLA-Bw54-DR4-DRw53 haplotype.

元の言語英語
ページ(範囲)9-17
ページ数9
ジャーナルHuman Immunology
22
発行部数1
DOI
出版物ステータス出版済み - 5 1988

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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