Immuno-wall lab-on-a-chip protein analysis devices for high precision surgery of gliomas

T. Kasama, A. Yamamichi, F. Ohka, Y. Kato, H. Suzuki, A. Kato, K. Motomura, M. Hirano, M. Ranjit, L. Chalise, M. Kurimoto, G. Kondo, K. Aoki, N. Kaji, T. Matsubara, H. Suzuki, M. Tokeshi, T. Wakabayashi, A. Natsume, Y. Baba

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

In the present study, we propose immuno-wall lab-on-a-chip protein analysis devices for ultrarapid detection of R132H mutant isocitrate dehydrogenase 1 (IDH1) that we identified as a specifically and commonly expressed gene in diffusely infiltrative gliomas1. In 9 min immunoassay, we successfully carried out specific detection of R132H mutant IDH1 in a lysate of glioma tissue, which is much faster than intraoperative pathological diagnosis. Moreover, clinical samples from 10 patients with gliomas were analyzed by using the immuno-wall devices. These results were consistent with those of PCR-based genetic mutation detection method. Our devices realize point-of-care tumor testing, resulting in the high precision surgery of gliomas.

本文言語英語
ホスト出版物のタイトル20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
出版社Chemical and Biological Microsystems Society
ページ651-652
ページ数2
ISBN(電子版)9780979806490
出版ステータス出版済み - 2016
外部発表はい
イベント20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, アイルランド
継続期間: 10 9 201610 13 2016

出版物シリーズ

名前20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

その他

その他20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
国/地域アイルランド
CityDublin
Period10/9/1610/13/16

All Science Journal Classification (ASJC) codes

  • 制御およびシステム工学

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