Immunogenetics of Hashimoto’s and Graves’ Diseases

Hajime Tamai, Hisamitsu Uno, Yoshihiko Hirota, Sunao Matsubayashi, Kanji Kuma, Hideo Matsumoto, Lindy F. Kumagai, Takehiko Sasazuki, Shigenobu Nagataki

研究成果: ジャーナルへの寄稿記事

48 引用 (Scopus)

抄録

Haplotypes of the human major histocompatibility complex (HLA) and the immunoglobulin allotype (Gm) were analyzed in all 243 members of 37 families in which 2 or more first degree relatives had Graves' disease. In 10 families with 70 members where 1 or more first degree relatives had Hashimoto’s disease, 26 (37%) had Graves’ disease, and 14 (20%) had Hashimoto’s disease. In the other 27 families, consisting of 173 members, 70 (40%) had Graves’ disease, and none had Hashimoto’s disease. The disease-associated haplotypes of HLA and Gm for each family were identified by determining the haplotypes concordant in 2 members with Graves’ disease. In 10 families with Graves’ and Hashimoto’s diseases, all 14 members with Hashimoto’s disease had the same disease-associated haplotypes of both HLA and Gm as had members with Graves’ disease in each family. Among 96 members with Graves’ disease in 37 families, 74 were used for the determination of the diseaseassociated haplotypes. In the remaining 22 members with Graves’ disease, 21 had both disease-associated haplotypes in their families. Our findings in these families suggest that 1) in Hashimoto’s disease as in Graves’ disease, two genes linked to HLA and Gm, respectively, control the susceptibility of the disease; 2) common immunogenetic factors are involved in the pathogenesis of both Hashimoto’s and Graves’ diseases, and 3) those who do not have immunogenetic factors are very unlikely to develop Hashimoto’s or Graves’ disease.

元の言語英語
ページ(範囲)62-66
ページ数5
ジャーナルJournal of Clinical Endocrinology and Metabolism
60
発行部数1
DOI
出版物ステータス出版済み - 1 1 1985

Fingerprint

Immunogenetics
Hashimoto Disease
Graves Disease
Haplotypes
Immunoglobulin Gm Allotypes
Disease Susceptibility
Major Histocompatibility Complex

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

これを引用

Tamai, H., Uno, H., Hirota, Y., Matsubayashi, S., Kuma, K., Matsumoto, H., ... Nagataki, S. (1985). Immunogenetics of Hashimoto’s and Graves’ Diseases. Journal of Clinical Endocrinology and Metabolism, 60(1), 62-66. https://doi.org/10.1210/jcem-60-1-62

Immunogenetics of Hashimoto’s and Graves’ Diseases. / Tamai, Hajime; Uno, Hisamitsu; Hirota, Yoshihiko; Matsubayashi, Sunao; Kuma, Kanji; Matsumoto, Hideo; Kumagai, Lindy F.; Sasazuki, Takehiko; Nagataki, Shigenobu.

:: Journal of Clinical Endocrinology and Metabolism, 巻 60, 番号 1, 01.01.1985, p. 62-66.

研究成果: ジャーナルへの寄稿記事

Tamai, H, Uno, H, Hirota, Y, Matsubayashi, S, Kuma, K, Matsumoto, H, Kumagai, LF, Sasazuki, T & Nagataki, S 1985, 'Immunogenetics of Hashimoto’s and Graves’ Diseases', Journal of Clinical Endocrinology and Metabolism, 巻. 60, 番号 1, pp. 62-66. https://doi.org/10.1210/jcem-60-1-62
Tamai H, Uno H, Hirota Y, Matsubayashi S, Kuma K, Matsumoto H その他. Immunogenetics of Hashimoto’s and Graves’ Diseases. Journal of Clinical Endocrinology and Metabolism. 1985 1 1;60(1):62-66. https://doi.org/10.1210/jcem-60-1-62
Tamai, Hajime ; Uno, Hisamitsu ; Hirota, Yoshihiko ; Matsubayashi, Sunao ; Kuma, Kanji ; Matsumoto, Hideo ; Kumagai, Lindy F. ; Sasazuki, Takehiko ; Nagataki, Shigenobu. / Immunogenetics of Hashimoto’s and Graves’ Diseases. :: Journal of Clinical Endocrinology and Metabolism. 1985 ; 巻 60, 番号 1. pp. 62-66.
@article{e3261fa8297542d9ba1b387ae8d61091,
title = "Immunogenetics of Hashimoto’s and Graves’ Diseases",
abstract = "Haplotypes of the human major histocompatibility complex (HLA) and the immunoglobulin allotype (Gm) were analyzed in all 243 members of 37 families in which 2 or more first degree relatives had Graves' disease. In 10 families with 70 members where 1 or more first degree relatives had Hashimoto’s disease, 26 (37{\%}) had Graves’ disease, and 14 (20{\%}) had Hashimoto’s disease. In the other 27 families, consisting of 173 members, 70 (40{\%}) had Graves’ disease, and none had Hashimoto’s disease. The disease-associated haplotypes of HLA and Gm for each family were identified by determining the haplotypes concordant in 2 members with Graves’ disease. In 10 families with Graves’ and Hashimoto’s diseases, all 14 members with Hashimoto’s disease had the same disease-associated haplotypes of both HLA and Gm as had members with Graves’ disease in each family. Among 96 members with Graves’ disease in 37 families, 74 were used for the determination of the diseaseassociated haplotypes. In the remaining 22 members with Graves’ disease, 21 had both disease-associated haplotypes in their families. Our findings in these families suggest that 1) in Hashimoto’s disease as in Graves’ disease, two genes linked to HLA and Gm, respectively, control the susceptibility of the disease; 2) common immunogenetic factors are involved in the pathogenesis of both Hashimoto’s and Graves’ diseases, and 3) those who do not have immunogenetic factors are very unlikely to develop Hashimoto’s or Graves’ disease.",
author = "Hajime Tamai and Hisamitsu Uno and Yoshihiko Hirota and Sunao Matsubayashi and Kanji Kuma and Hideo Matsumoto and Kumagai, {Lindy F.} and Takehiko Sasazuki and Shigenobu Nagataki",
year = "1985",
month = "1",
day = "1",
doi = "10.1210/jcem-60-1-62",
language = "English",
volume = "60",
pages = "62--66",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "1",

}

TY - JOUR

T1 - Immunogenetics of Hashimoto’s and Graves’ Diseases

AU - Tamai, Hajime

AU - Uno, Hisamitsu

AU - Hirota, Yoshihiko

AU - Matsubayashi, Sunao

AU - Kuma, Kanji

AU - Matsumoto, Hideo

AU - Kumagai, Lindy F.

AU - Sasazuki, Takehiko

AU - Nagataki, Shigenobu

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Haplotypes of the human major histocompatibility complex (HLA) and the immunoglobulin allotype (Gm) were analyzed in all 243 members of 37 families in which 2 or more first degree relatives had Graves' disease. In 10 families with 70 members where 1 or more first degree relatives had Hashimoto’s disease, 26 (37%) had Graves’ disease, and 14 (20%) had Hashimoto’s disease. In the other 27 families, consisting of 173 members, 70 (40%) had Graves’ disease, and none had Hashimoto’s disease. The disease-associated haplotypes of HLA and Gm for each family were identified by determining the haplotypes concordant in 2 members with Graves’ disease. In 10 families with Graves’ and Hashimoto’s diseases, all 14 members with Hashimoto’s disease had the same disease-associated haplotypes of both HLA and Gm as had members with Graves’ disease in each family. Among 96 members with Graves’ disease in 37 families, 74 were used for the determination of the diseaseassociated haplotypes. In the remaining 22 members with Graves’ disease, 21 had both disease-associated haplotypes in their families. Our findings in these families suggest that 1) in Hashimoto’s disease as in Graves’ disease, two genes linked to HLA and Gm, respectively, control the susceptibility of the disease; 2) common immunogenetic factors are involved in the pathogenesis of both Hashimoto’s and Graves’ diseases, and 3) those who do not have immunogenetic factors are very unlikely to develop Hashimoto’s or Graves’ disease.

AB - Haplotypes of the human major histocompatibility complex (HLA) and the immunoglobulin allotype (Gm) were analyzed in all 243 members of 37 families in which 2 or more first degree relatives had Graves' disease. In 10 families with 70 members where 1 or more first degree relatives had Hashimoto’s disease, 26 (37%) had Graves’ disease, and 14 (20%) had Hashimoto’s disease. In the other 27 families, consisting of 173 members, 70 (40%) had Graves’ disease, and none had Hashimoto’s disease. The disease-associated haplotypes of HLA and Gm for each family were identified by determining the haplotypes concordant in 2 members with Graves’ disease. In 10 families with Graves’ and Hashimoto’s diseases, all 14 members with Hashimoto’s disease had the same disease-associated haplotypes of both HLA and Gm as had members with Graves’ disease in each family. Among 96 members with Graves’ disease in 37 families, 74 were used for the determination of the diseaseassociated haplotypes. In the remaining 22 members with Graves’ disease, 21 had both disease-associated haplotypes in their families. Our findings in these families suggest that 1) in Hashimoto’s disease as in Graves’ disease, two genes linked to HLA and Gm, respectively, control the susceptibility of the disease; 2) common immunogenetic factors are involved in the pathogenesis of both Hashimoto’s and Graves’ diseases, and 3) those who do not have immunogenetic factors are very unlikely to develop Hashimoto’s or Graves’ disease.

UR - http://www.scopus.com/inward/record.url?scp=0021968814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021968814&partnerID=8YFLogxK

U2 - 10.1210/jcem-60-1-62

DO - 10.1210/jcem-60-1-62

M3 - Article

C2 - 3838076

AN - SCOPUS:0021968814

VL - 60

SP - 62

EP - 66

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 1

ER -