Immunohistochemical study of neuron specific enolase and S-100 protein in Hirschsprung's disease

Tomoaki Taguchi, Kenzo Tanaka, Keiichi Ikeda

研究成果: ジャーナルへの寄稿学術誌査読

42 被引用数 (Scopus)


The distribution of whole differentiated neurons in the intestines from 15 children with Hirschsprung's disease was investigated using neuron specific enolase (NSE) and the perineuronal elements were studied using S-100 protein immunostaining. In aganglionic segments, NSE immunoreactive ganglion cells and S-100 positive satellite cells were absent, but the hypertrophic nerve trunks did show a markedly positive NSE and S-100 immunoreactivity. Two different forms of aganglionic segment were present. One was the middle aganglionic segment of long segment aganglionosis which was almost completely dennervated. In the other type, there were several NSE positive nerve fibers in the muscularis propria of both the aganglionic segment of short segment aganglionosis and the distal aganglionic segment of long segment aganglionosis. These latter two aganglionic segments seemed to be innervated by extrinsic nerves.

ジャーナルVirchows Archiv A Pathological Anatomy and Histopathology
出版ステータス出版済み - 12月 1985

All Science Journal Classification (ASJC) codes

  • 病理学および法医学


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