Immunohistochemical study of neuron specific enolase and S-100 protein in Hirschsprung's disease

Tomoaki Taguchi, Kenzo Tanaka, Keiichi Ikeda

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)

抄録

The distribution of whole differentiated neurons in the intestines from 15 children with Hirschsprung's disease was investigated using neuron specific enolase (NSE) and the perineuronal elements were studied using S-100 protein immunostaining. In aganglionic segments, NSE immunoreactive ganglion cells and S-100 positive satellite cells were absent, but the hypertrophic nerve trunks did show a markedly positive NSE and S-100 immunoreactivity. Two different forms of aganglionic segment were present. One was the middle aganglionic segment of long segment aganglionosis which was almost completely dennervated. In the other type, there were several NSE positive nerve fibers in the muscularis propria of both the aganglionic segment of short segment aganglionosis and the distal aganglionic segment of long segment aganglionosis. These latter two aganglionic segments seemed to be innervated by extrinsic nerves.

元の言語英語
ページ(範囲)399-409
ページ数11
ジャーナルVirchows Archiv A Pathological Anatomy and Histopathology
405
発行部数4
DOI
出版物ステータス出版済み - 12 1 1985

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Hirschsprung Disease
S100 Proteins
Phosphopyruvate Hydratase
Nerve Fibers
Ganglia
Intestines
Neurons

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

これを引用

Immunohistochemical study of neuron specific enolase and S-100 protein in Hirschsprung's disease. / Taguchi, Tomoaki; Tanaka, Kenzo; Ikeda, Keiichi.

:: Virchows Archiv A Pathological Anatomy and Histopathology, 巻 405, 番号 4, 01.12.1985, p. 399-409.

研究成果: ジャーナルへの寄稿記事

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