Immunohistochemistry of chondromodulin-I in the human intervertebral discs with special reference to the degenerative changes

Tsuneaki Takao, Toru Iwaki, Jun Kondo, Yuji Hiraki

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

The expression of the matrix protein chondromodulin-I has been studied in human intervertebral discs of 101 people using immunohistochemical analyses. The purpose of this report is to present data on the metabolic changes that were found to occur in the chondrocytes of intervertebral discs during development and aging. Chondromodulin-I was highly expressed during the gestational period and gradually decreased after maturation. It was detected in both the extracellular matrix and chondrocytes in the zone of hypertrophic cartilage, the zone of proliferative cartilage and the zone of resting cartilage in fetal discs. It was also present in the annulus fibrosus, nucleus pulposus and end-plate cartilage in mature discs. In degenerative discs, chondromodulin-I immunoreactivity tended to be elevated in the remaining chondrocytes. Our findings suggest that the expression of the protein is developmentally regulated and upregulated through a defense mechanism against the degenerative processes of the aged intervertebral disc.

本文言語英語
ページ(範囲)545-550
ページ数6
ジャーナルHistochemical Journal
32
9
DOI
出版ステータス出版済み - 2000

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Cell Biology

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