Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia: A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation

S. Nishiwaki, K. Miyamura, K. Ohashi, M. Kurokawa, S. Taniguchi, T. Fukuda, K. Ikegame, S. Takahashi, T. Mori, K. Imai, H. Iida, M. Hidaka, H. Sakamaki, Y. Morishima, K. Kato, R. Suzuki, J. Tanaka

研究成果: Contribution to journalArticle査読

21 被引用数 (Scopus)

抄録

Background: We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). Patients and methods: We retrospectively analyzed data of 1726 patients who underwent myeloablative allo-SCT for adult Ph(-) ALL. The sources of the allo-SCT were related donors (RD; N = 684), unrelated donors (URD; N = 809), and CB (N = 233). Results: Overall survival (OS) in patients after CB allo-SCT in first complete remission (CR1) was comparable with that after RD or URD allo-SCT (RD: 65%, URD: 64% and CB: 57% at 4 years, P = 0.11). CB was not a significant risk factor for relapse or non-relapse mortality as well as for OS in multivariate analyses. Similarly, the donor source was not a significant risk factor for OS in subsequent CR or non-CR (RD: 47%, URD: 39% and CB: 48% in subsequent CR, P = 0.33; RD: 15%, URD: 21% and CB: 18% in non-CR, P = 0.20 at 4 years). Conclusion: Allo-SCT using CB led to OS similar to those of RD or URD in any disease status. To avoid missing the appropriate timing, CB is a favorable alternative source for adult Ph(-) ALL patients without a suitable RD or URD.

本文言語英語
ページ(範囲)1594-1602
ページ数9
ジャーナルAnnals of Oncology
24
6
DOI
出版ステータス出版済み - 6 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 血液学
  • 腫瘍学

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