Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients: The Q-Cohort Study

Shigeru Tanaka, Toshiharu Ninomiya, Masatomo Taniguchi, Masanori Tokumoto, Kosuke Masutani, Hiroaki Ooboshi, Takanari Kitazono, Kazuhiko Tsuruya

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

The association between blood urea nitrogen to creatinine ratio (UCR) and survival is uncertain in hemodialysis patients. We examined the influence of UCR on mortality and morbidity in hemodialysis patients. A total of 3,401 hemodialysis patients were prospectively followed for 4 years. The association between UCR with overall survival was analyzed using a Cox regression model. During a 4-year follow-up period, 545 patients died from any cause and 582 experienced MACE, 392 with coronary heart disease (CHD), 114 with infection-related death, 77 with hemorrhagic stroke, 141 with ischemic stroke, and 107 with cancer death. Every 1 increase in UCR level was significantly associated with an increased risk for all-cause mortality (hazard ratio [HR] 1.07; 95% confidence interval [CI] 1.03-1.12), CHD (HR 1.08; 95% CI 1.02-1.14), and infection-related death (HR 1.11; 95% CI 1.02-1.21). There was no evidence of a significant association between UCR and death from cancer, and incidence of stroke. A high UCR was significantly associated with an increased risk for all-cause mortality, infection-related death and incidence of CHD in hemodialysis patients.

元の言語英語
記事番号14901
ジャーナルScientific reports
7
発行部数1
DOI
出版物ステータス出版済み - 12 1 2017

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Blood Urea Nitrogen
Renal Dialysis
Creatinine
Cohort Studies
Morbidity
Mortality
Coronary Disease
Stroke
Confidence Intervals
Infection
Survival
Incidence
Proportional Hazards Models
Neoplasms

All Science Journal Classification (ASJC) codes

  • General

これを引用

Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients : The Q-Cohort Study. / Tanaka, Shigeru; Ninomiya, Toshiharu; Taniguchi, Masatomo; Tokumoto, Masanori; Masutani, Kosuke; Ooboshi, Hiroaki; Kitazono, Takanari; Tsuruya, Kazuhiko.

:: Scientific reports, 巻 7, 番号 1, 14901, 01.12.2017.

研究成果: ジャーナルへの寄稿記事

Tanaka, Shigeru ; Ninomiya, Toshiharu ; Taniguchi, Masatomo ; Tokumoto, Masanori ; Masutani, Kosuke ; Ooboshi, Hiroaki ; Kitazono, Takanari ; Tsuruya, Kazuhiko. / Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients : The Q-Cohort Study. :: Scientific reports. 2017 ; 巻 7, 番号 1.
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