Impact of Ca2+ signaling on B cell function

Yoshihiro Baba, Tomohiro Kurosaki

研究成果: Contribution to journalReview article査読

48 被引用数 (Scopus)

抄録

In B cells, changes in intracellular concentration of Ca2+ drive signal transduction to initiate changes in gene expression and various cellular events, including apoptosis and differentiation. B cell receptor engagement causes a transient Ca2+ flux from the endoplasmic reticulum Ca2+ store, followed by a continuous increase in intracellular Ca2+ concentration, mainly resulting from store-operated Ca2+ entry (SOCE). The recent identification of stromal interaction molecule (STIM) and Orai as essential components for SOCE has allowed researchers to probe further the role of Ca2+ signals in B cell biology. Here, we summarize the B cell signaling pathways that lead to SOCE, the role of Ca2+ signals in B cell regulatory function, and how a breakdown in the balance of Ca2+ signals is associated with immune-related disease.

本文言語英語
ページ(範囲)589-594
ページ数6
ジャーナルTrends in Immunology
32
12
DOI
出版ステータス出版済み - 12 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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