Impact of exercise training on ventricular properties in a canine model of congestive heart failure

Koji Todaka, Jie Wang, Geng Hua Yi, Mathias Knecht, Richard Stennett, Milton Packer, Daniel Burkhoff

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)


Exercise training improves functional class in patients with chronic heart failure (CHF) via effects on the periphery with no previously documented effect on intrinsic left ventricular (LV) properties. However, because methods used to evaluate in vivo LV function are limited, it is possible that some effects of exercise training on the failing heart have thus far eluded detection. Twelve dogs were instrumented for cardiac pacing and hemodynamic recordings. Hearts were paced rapidly for 4 wk. Six of the dogs received daily treadmill exercise (CHF(EX), 4.4 km/h, 2 h/day) concurrent with rapid pacing, while the other dogs remained sedentary (CHF(S)). Hemodynamic measurements taken in vivo at the end of 4 wk revealed relative preservation of maximum rate of pressure rise (2,540 ± 440 vs. 1,720 ± 300 mmHg/s, P < 0.05) and LV end-diastolic pressure (9 ± 5 vs. 19 ± 4 mmHg, P < 0.05) in CHF(EX) compared with CHF(S). The hearts were then isolated and cross perfused for in vitro measurement of isovolumic pressure- volume relations; these results were compared with those of six normal dogs (N). Systolic function was similarly depressed in both groups of pacing animals [end-systolic elastance (E(es)) values of 1.66 ± 0.47 in CHF(S), 1.77 ± 0.38 in CHF(EX), and 3.05 ± 0.81 mmHg/ml in N, with no changes in volume axis interceptors of the end-systolic pressure-volume relationship]. The diastolic myocardial stiffness constant, k, was elevated in CHF(S) and was normalized by exercise training (32 ± 3 in CHF(S), 21 ± 3 in CHF(EX), 20 ± 4 in N). Thus daily exercise training preserved in vivo hemodynamics during 4 wk of rapid cardiac pacing and was accompanied by a significant change in diastolic myocardial stiffness in vitro. These findings suggest that changes in heart function may contribute to the overall beneficial hemodynamic effects of exercise training in CHF by a significant effect on diastolic properties.

ジャーナルAmerican Journal of Physiology - Heart and Circulatory Physiology
3 41-3
出版ステータス出版済み - 3月 1997

!!!All Science Journal Classification (ASJC) codes

  • 生理学
  • 循環器および心血管医学
  • 生理学(医学)


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