Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation

Hideya Kamei, Satohiro Masuda, Taro Nakamura, Yasuhiro Fujimoto, Fumitaka Oike, Yasuhiro Ogura, Yasutsugu Takada, Nobuyuki Hamajima

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

It has previously been demonstrated that glutathione S-transferase T1 (GSTT1) genetic mismatch between recipient and donor is a risk factor for developing immune-mediated hepatitis following liver transplantation and for antibody-mediated rejection in renal transplantation. Little is known whether the GSTT1 gene polymorphism affects the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Patients underwent LDLT at Nagoya University or Kyoto University, Japan, between 2004 and 2009. Genotyping of GSTT1 genes (null or present genotype) was conducted in recipients and donors. A total of 155 LDLT cases were examined. Forty-seven recipients (30.3%) developed early ACR. There was no association of recipient GSTT1 genotype with ACR incidence. However, ACR incidence was significantly higher in recipients transplanted from GSTT1 present genotype donors than in those transplanted from GSTT1 null genotype donors [odds ratio (OR). =. 2.64, 95% confidence interval (CI). =. 1.12-5.83, p=. 0.016]. Moreover, GSTT1 recipient/donor genotype mismatch (present/null or null/present) was significantly associated with ACR development (OR. =. 2.28, 95% CI. =. 1.12-4.61, p=. 0.022). The genotyping of GSTT1 in recipients and donors might be useful to stratify the liver transplant recipients according to risk of ACR.

本文言語英語
ページ(範囲)14-17
ページ数4
ジャーナルTransplant Immunology
28
1
DOI
出版ステータス出版済み - 1 2013

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 移植

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