Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry

Yuji Komorita, Masanori Iwase, Yasuhiro Idewaki, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Masahito Yoshinari, Ai Murao-Kimura, Yutaro Oku, Udai Nakamura, Takanari Kitazono

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Aims/Introduction: Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all-cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end-stage renal disease (ERSD). Materials and Methods: In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow-up rate 99.5%). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all-cause death by logistic regression analysis. Results: A total of 309 participants died during follow up. Multivariate-adjusted odds ratios (ORs) for all-cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95% confidence interval [CI] 1.54–4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all-cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95% CI, 1.39–2.70) and ESRD (OR 2.36, 95% CI 1.32–4.05). The ORs for all-cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95% CI 1.58–4.54). The cause of death was infection (40.0%), malignant neoplasm (25.0%) and CVD (15.0%) among participants with hip fracture. Conclusions: Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.

元の言語英語
ジャーナルJournal of Diabetes Investigation
DOI
出版物ステータス出版済み - 1 1 2019

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Hip Fractures
Registries
Diabetes Mellitus
Odds Ratio
Cardiovascular Diseases
Mortality
Chronic Kidney Failure
Confidence Intervals
Cause of Death
Upper Extremity
Logistic Models
Regression Analysis
Infection

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

これを引用

Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus : The Fukuoka Diabetes Registry. / Komorita, Yuji; Iwase, Masanori; Idewaki, Yasuhiro; Fujii, Hiroki; Ohkuma, Toshiaki; Ide, Hitoshi; Jodai-Kitamura, Tamaki; Yoshinari, Masahito; Murao-Kimura, Ai; Oku, Yutaro; Nakamura, Udai; Kitazono, Takanari.

:: Journal of Diabetes Investigation, 01.01.2019.

研究成果: ジャーナルへの寄稿記事

Komorita, Yuji ; Iwase, Masanori ; Idewaki, Yasuhiro ; Fujii, Hiroki ; Ohkuma, Toshiaki ; Ide, Hitoshi ; Jodai-Kitamura, Tamaki ; Yoshinari, Masahito ; Murao-Kimura, Ai ; Oku, Yutaro ; Nakamura, Udai ; Kitazono, Takanari. / Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus : The Fukuoka Diabetes Registry. :: Journal of Diabetes Investigation. 2019.
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title = "Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry",
abstract = "Aims/Introduction: Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all-cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end-stage renal disease (ERSD). Materials and Methods: In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow-up rate 99.5{\%}). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all-cause death by logistic regression analysis. Results: A total of 309 participants died during follow up. Multivariate-adjusted odds ratios (ORs) for all-cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95{\%} confidence interval [CI] 1.54–4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all-cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95{\%} CI, 1.39–2.70) and ESRD (OR 2.36, 95{\%} CI 1.32–4.05). The ORs for all-cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95{\%} CI 1.58–4.54). The cause of death was infection (40.0{\%}), malignant neoplasm (25.0{\%}) and CVD (15.0{\%}) among participants with hip fracture. Conclusions: Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.",
author = "Yuji Komorita and Masanori Iwase and Yasuhiro Idewaki and Hiroki Fujii and Toshiaki Ohkuma and Hitoshi Ide and Tamaki Jodai-Kitamura and Masahito Yoshinari and Ai Murao-Kimura and Yutaro Oku and Udai Nakamura and Takanari Kitazono",
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TY - JOUR

T1 - Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus

T2 - The Fukuoka Diabetes Registry

AU - Komorita, Yuji

AU - Iwase, Masanori

AU - Idewaki, Yasuhiro

AU - Fujii, Hiroki

AU - Ohkuma, Toshiaki

AU - Ide, Hitoshi

AU - Jodai-Kitamura, Tamaki

AU - Yoshinari, Masahito

AU - Murao-Kimura, Ai

AU - Oku, Yutaro

AU - Nakamura, Udai

AU - Kitazono, Takanari

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aims/Introduction: Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all-cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end-stage renal disease (ERSD). Materials and Methods: In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow-up rate 99.5%). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all-cause death by logistic regression analysis. Results: A total of 309 participants died during follow up. Multivariate-adjusted odds ratios (ORs) for all-cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95% confidence interval [CI] 1.54–4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all-cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95% CI, 1.39–2.70) and ESRD (OR 2.36, 95% CI 1.32–4.05). The ORs for all-cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95% CI 1.58–4.54). The cause of death was infection (40.0%), malignant neoplasm (25.0%) and CVD (15.0%) among participants with hip fracture. Conclusions: Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.

AB - Aims/Introduction: Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all-cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end-stage renal disease (ERSD). Materials and Methods: In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow-up rate 99.5%). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all-cause death by logistic regression analysis. Results: A total of 309 participants died during follow up. Multivariate-adjusted odds ratios (ORs) for all-cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95% confidence interval [CI] 1.54–4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all-cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95% CI, 1.39–2.70) and ESRD (OR 2.36, 95% CI 1.32–4.05). The ORs for all-cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95% CI 1.58–4.54). The cause of death was infection (40.0%), malignant neoplasm (25.0%) and CVD (15.0%) among participants with hip fracture. Conclusions: Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.

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DO - 10.1111/jdi.13076

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