TY - JOUR
T1 - Impact of reactive oxygen and nitrogen species produced by plasma on mdm2–p53 complex
AU - Attri, Pankaj
AU - Kurita, Hirofumi
AU - Koga, Kazunori
AU - Shiratani, Masaharu
N1 - Funding Information:
This work is supported by R3QR Program (Qdai-jump Research Program) 01257 and JSPS-KAKENHI grant 20K14454 and 20H01893. Additionally, it is partly supported by JSPS-KAKENHI grant 21H01074, 21H04451 and 19H05462, and Plasma Bio Consortium, Center for Low-Temperature Plasma Sciences, Nagoya University.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/9
Y1 - 2021/9
N2 - The study of protein–protein interactions is of great interest. Several early studies focused on the murine double minute 2 (Mdm2)–tumor suppressor protein p53 interactions. However, the effect of plasma treatment on Mdm2 and p53 is still absent from the literature. This study investigated the structural changes in Mdm2, p53, and the Mdm2–p53 complex before and after possible plasma oxidation through molecular dynamic (MD) simulations. MD calculation revealed that the oxidized Mdm2 bounded or unbounded showed high flexibility that might increase the availability of tumor suppressor protein p53 in plasma-treated cells. This study provides insight into Mdm2 and p53 for a better understanding of plasma oncology.
AB - The study of protein–protein interactions is of great interest. Several early studies focused on the murine double minute 2 (Mdm2)–tumor suppressor protein p53 interactions. However, the effect of plasma treatment on Mdm2 and p53 is still absent from the literature. This study investigated the structural changes in Mdm2, p53, and the Mdm2–p53 complex before and after possible plasma oxidation through molecular dynamic (MD) simulations. MD calculation revealed that the oxidized Mdm2 bounded or unbounded showed high flexibility that might increase the availability of tumor suppressor protein p53 in plasma-treated cells. This study provides insight into Mdm2 and p53 for a better understanding of plasma oncology.
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U2 - 10.3390/ijms22179585
DO - 10.3390/ijms22179585
M3 - Article
C2 - 34502494
AN - SCOPUS:85114226382
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 17
M1 - 9585
ER -