Impact of single nucleotide polymorphisms in glutathione S transferase gene GSTP1 in the treatment with oxaliplatin based chemotherapy

Eiji Oki, Yoshihiro Kakeji, Kippei Ohgaki, Kohji Saeki, Masaru Morita, Yasunori Emi, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

Oxaliplatin has been the main treatment of choice in colorectal cancer in advanced settings. However, cellular mechanisms for the uptake, intracellular distribution and efflux of oxaliplatin are unknown. GST(glutathione S transferase)is member of a superfamily of metabolic enzymes that play an important role in the cell defense system. Current data suggest that GST-pi is associated with increased resistance to platinum-based chemotherapy. Specific roles for the single nucleotide polymorphisms in GST-pi gene GSTP1 in the treatment with oxaliplatin based chemotherapy, have been demonstrated in recent years.

本文言語英語
ページ(範囲)1094-1096
ページ数3
ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
35
7
出版ステータス出版済み - 7月 2008

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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