Impact of the Direction of HLA Mismatch on Transplantation Outcomes in Single Unrelated Cord Blood Transplantation

Junya Kanda, Yoshiko Atsuta, Atsushi Wake, Tatsuo Ichinohe, Minoko Takanashi, Yasuo Morishima, Shuichi Taniguchi, Satoshi Takahashi, Hiroyasu Ogawa, Kazuteru Ohashi, Yuju Ohno, Nobuyuki Aotsuka, Yasushi Onishi, Koji Kato, Tokiko Nagamura-Inoue, Yoshinobu Kanda

    研究成果: Contribution to journalArticle査読

    31 被引用数 (Scopus)

    抄録

    The impact of the direction of HLA mismatch (MM) on outcome in unrelated cord blood (UCB) transplantation has not yet been clarified. We conducted a retrospective study using national registry data on 2977 patients who underwent transplantation using a single UCB for leukemia or myelodysplastic syndrome. HLA matching was assessed by serologic data for HLA-A, -B, and -DR loci. The median age of the recipients at transplantation was 41 years (range, 0-82 years), and 2300 recipients (77%) were age ≥16 years. The 2-year overall survival rate was 0.46. The presence of MM only in the graft-versus-host direction or only in the host-versus-graft direction was not associated with overall mortality (hazard ratio [HR], 0.88; . P = .317 and HR, 0.95; . P = .670, respectively) compared with 1 bidirectional MM. This finding was consistent in both the child and adult cohorts. The presence of MM only in the graft-versus-host direction was associated with a lower incidence of nonrelapse mortality (HR, 0.65; . P = .040), significant only in the child cohort. No MM category was associated with relapse. Our findings suggest that the direction of HLA MM does not have a significant impact on overall survival after UCB transplantation.

    本文言語英語
    ページ(範囲)247-254
    ページ数8
    ジャーナルBiology of Blood and Marrow Transplantation
    19
    2
    DOI
    出版ステータス出版済み - 2 2013

    All Science Journal Classification (ASJC) codes

    • Hematology
    • Transplantation

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