Impacts of Stressful Life Events and Traumatic Experiences on Onset of Obsessive-Compulsive Disorder

Keitaro Murayama, Tomohiro Nakao, Aikana Ohno, Sae Tsuruta, Hirofumi Tomiyama, Suguru Hasuzawa, Taro Mizobe, Kenta Kato, Shigenobu Kanba

研究成果: ジャーナルへの寄稿学術誌査読

9 被引用数 (Scopus)


Not a few patients with obsessive-compulsive disorder (OCD) have experienced events that affected the onset. The onset of OCD is not limited to the original meaning of trauma; rather, traumatic experiences such as unexpected exposure to contaminants or various stressful life events often cause the onset of OCD. It would be useful to understand the experiences surrounding the onset, including stressful life events and traumatic experiences, for comprehension of the pathophysiology of OCD. In the present study, we investigated the onset conditions of 281 patients with OCD and compared clinical characteristics among groups with or without stressful life events including traumatic experiences. As a result, 172 (61.2%) participants had experienced various stressful life events, and 98 (34%) participants had had traumatic experiences before the onset. Furthermore, the participants who had had stressful life events showed more contamination/fear symptoms compared with those without such life events. Meanwhile, the patients who had had specific traumatic experiences showed a tendency toward hoarding obsessions. To comprehend the pathophysiology of OCD, it is important to understand the stressful life events that precede its onset.

ジャーナルFrontiers in Psychiatry
出版ステータス出版済み - 12月 3 2020

!!!All Science Journal Classification (ASJC) codes

  • 精神医学および精神衛生


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