Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice

Nobuaki Egashira, Akito Tanoue, Tomomi Matsuda, Emi Koushi, Satoko Harada, Yukio Takano, Gozoh Tsujimoto, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara

研究成果: Contribution to journalArticle査読

119 被引用数 (Scopus)

抄録

The arginine vasopressin (AVP) system plays an important role in social behavior. Autism, with its hallmark disturbances in social behavior, has been associated with the V1a receptor (V1aR) gene. Furthermore, impairments of social function are often observed in symptoms of schizophrenia. Subchronic phencyclidine (PCP) produces behaviors relating to certain aspects of schizophrenic symptoms such as impairing social interaction in animals and it reduces the density of V1aR binding sites in several brain regions. Here, we report that V1aR knockout (KO) mice exhibited impairment of social behavior in a social interaction test, and showed reduced anxiety-related behavior in elevated plus-maze and marble-burying behavior tests. Given the current findings, the V1aR may be involved in the regulation of social interaction, and V1aR KO mice could be used as an animal model of psychiatric disorders associated with social behavior deficits, such as autism and schizophrenia.

本文言語英語
ページ(範囲)123-127
ページ数5
ジャーナルBehavioural Brain Research
178
1
DOI
出版ステータス出版済み - 3 12 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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