Impaired Tumor Phenotypes in Class II Major Histocompatibility Complex Antigen-Inducible Cells Originated from Human Lung Adenocarcinoma

S. Kawamoto, Y. Inoue, Y. Shinozaki, Yoshinori Katakura, Hirofumi Tachibana, S. Shirahata, H. Murakami

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

The class II major histocompatibility complex (MHC) antigens play important roles in T cell activation and are thought to be involved in tumor development. Using anti-class II antibodies with interferon gamma (IFN-γ), we have here selected class II MHC antigen positive cancer cells from the human lung adenocarcinoma cell line A549, which is originally negative (>95%) for the antigens. A part of the class II antigen-positive cells presented a flat morphology, which was not observed in the parental A549 cells. Class II antigen expression in these flat cells was IFN-γ, inducible; there was a correlation between the inducibility and phenotypic changes. A class II antigen-inducible flat subline restored the ability of contact inhibition and anchorage-dependent growth as well as lost tumorigenicity in athymic mice.

本文言語英語
ページ(範囲)280-285
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
215
1
DOI
出版ステータス出版済み - 10月 4 1995

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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