Implication of circulating memory B cells in late-onset myasthenia gravis

Abstract Myasthenia gravis is a heterogeneous disease, and it presents various clinical differences according to the age of onset. Immunological backgrounds that cause these differences are not well understood. Kubota et al. investigated subsets of circulating T and B lymphocytes using various markers. They argued that a reduced percentage of memory B cells seems to be a characteristic of late-onset myasthenia gravis.