Implication of soluble forms of cell adhesion molecules in infectious disease and tumor: Insights from transgenic animal models

Etsuro Ono, Toshimitsu Uede

研究成果: ジャーナルへの寄稿評論記事

2 引用 (Scopus)

抄録

Cell adhesion molecules (CAMs) are surface ligands, usually glycoproteins, which mediate cell-to-cell adhesion. They play a critical role in maintaining tissue integrity and mediating migration of cells, and some of them also act as viral receptors. It has been known that soluble forms of the viral receptors bind to the surface glycoproteins of the viruses and neutralize them, resulting in inhibition of the viral entry into cells. Nectin-1 is one of important CAMs belonging to immunoglobulin superfamily and herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor family. Both CAMs also act as alphaherpesvirus receptor. Transgenic mice expressing the soluble form of nectin-1 or HVEM showed almost complete resistance against the alphaherpesviruses. As another CAM, sialic acid-binding immunoglobulin-like lectins (Siglecs) that recognize sialic acids are also known as an immunoglobulin superfamily member. Siglecs play an important role in the regulation of immune cell functions in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer. Siglec-9 is one of Siglecs and capsular polysaccharide (CPS) of group B Streptococcus (GBS) binds to Siglec-9 on neutrophils, leading to suppress host immune response and provide a survival advantage to the pathogen. In addition, Siglec-9 also binds to tumor-produced mucins such as MUC1 to lead negative immunomodulation. Transgenic mice expressing the soluble form of Siglec-9 showed significant resistance against GBS infection and remarkable suppression of MUC1 expressing tumor proliferation. This review describes recent developments in the understanding of the potency of soluble forms of CAMs in the transgenic mice and discusses potential therapeutic interventions that may alter the outcomes of certain diseases.

元の言語英語
記事番号239
ジャーナルInternational journal of molecular sciences
19
発行部数1
DOI
出版物ステータス出版済み - 1 13 2018

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Sialic Acid Binding Immunoglobulin-like Lectins
Genetically Modified Animals
animal models
Cell adhesion
Cell Adhesion Molecules
infectious diseases
Communicable Diseases
Tumors
Animals
adhesion
tumors
Animal Models
Molecules
cells
Receptors, Tumor Necrosis Factor, Member 14
molecules
Neoplasms
Glycoproteins
Transgenic Mice
Acids

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

これを引用

Implication of soluble forms of cell adhesion molecules in infectious disease and tumor : Insights from transgenic animal models. / Ono, Etsuro; Uede, Toshimitsu.

:: International journal of molecular sciences, 巻 19, 番号 1, 239, 13.01.2018.

研究成果: ジャーナルへの寄稿評論記事

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