Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes

Masutaka Furue, Uchi Hiroshi, Chikage Mitoma, Akiko Hashimoto-Hachiya, Yuka Tanaka, Takamichi Ito, Gaku Tsuji

研究成果: ジャーナルへの寄稿評論記事

1 引用 (Scopus)

抄録

Ultraviolet B (UVB) irradiation activates aryl hydrocarbon receptor (AHR), generates reactive oxygen species (ROS) and mediates photocarcinogenesis and photoaging. 6-Formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct generated by UVB exposure. FICZ exhibits similar biological effects to UVB, including AHR ligation and ROS production. FICZ also acts as a potent photosensitizer for UVA and the production of ROS is synergistically augmented in the simultaneous presence of FICZ and UVA. In contrast, FICZ upregulates the expression of terminal differentiation molecules such as filaggrin and loricrin via AHR. In parallel with this, the administration of FICZ inhibits skin inflammation in a murine psoriasis and dermatitis model. In this article, we summarize the harmful and beneficial aspects of FICZ in skin pathology.

元の言語英語
ページ(範囲)37-41
ページ数5
ジャーナルGiornale Italiano di Dermatologia e Venereologia
154
発行部数1
DOI
出版物ステータス出版済み - 2 1 2019

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Aryl Hydrocarbon Receptors
Keratinocytes
Tryptophan
Reactive Oxygen Species
Oxidative Stress
Skin
Photosensitizing Agents
Dermatitis
Psoriasis
Ligation
Up-Regulation
Pathology
Inflammation

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes. / Furue, Masutaka; Hiroshi, Uchi; Mitoma, Chikage; Hashimoto-Hachiya, Akiko; Tanaka, Yuka; Ito, Takamichi; Tsuji, Gaku.

:: Giornale Italiano di Dermatologia e Venereologia, 巻 154, 番号 1, 01.02.2019, p. 37-41.

研究成果: ジャーナルへの寄稿評論記事

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AU - Furue, Masutaka

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AU - Mitoma, Chikage

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AU - Tanaka, Yuka

AU - Ito, Takamichi

AU - Tsuji, Gaku

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