Importance of interaction between C1 domain and lipids in protein kinase Cα activation: Hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level

Go Hirai, Adashi Shimizu, Toru Watanabe, Yosuke Ogoshi, Megumi Ohkubo, Mikiko Sodeoka

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Substituent direction is important: Type A-D isobenzofuranone derivatives were synthesized with differently directed hydrophobic alkyl side chains. These ligands bind in a similar conformation to protein kinase Cα but have contrasting activation abilities, possibly owing to different interaction of the side chain with the membrane lipid. (Chemical Equation Presented)

本文言語英語
ページ(範囲)1006-1009
ページ数4
ジャーナルChemMedChem
2
7
DOI
出版ステータス出版済み - 7 9 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 薬理学
  • 創薬
  • 薬理学、毒性学および薬学(全般)
  • 有機化学

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