Imprinting and looping: Epigenetic marks control interactions between regulatory elements

Yuzuru Kato, Hiroyuki Sasaki

研究成果: Contribution to journalReview article査読

24 被引用数 (Scopus)

抄録

Gene regulation involves various cis-regulatory elements that can act at a distance. They may physically interact each other or with their target genes to exert their effects. Such interactions are beginning to be uncovered in the imprinted lgf2/H19 domain. The differentially methylated regions (DMRs), containing insulators, silencers and activators, were shown to have physical contacts between them. The interactions were changeable depending on their epigenetic state, presumably enabling lgf2 to move between an active and a silent chromatin domain. The study gives us a novel view on how regulatory elements influence gene expression and how epigenetic modifications modulate their long-range effects.

本文言語英語
ページ(範囲)1-4
ページ数4
ジャーナルBioEssays
27
1
DOI
出版ステータス出版済み - 1 1 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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