Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens

Kazutoshi Aoyama, Motoko Koyama, Ken Ichi Matsuoka, Daigo Hashimoto, Tatsuo Ichinohe, Mine Harada, Koichi Akashi, Mitsune Tanimoto, Takanori Teshima

研究成果: Contribution to journalArticle

32 引用 (Scopus)

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Exposure of offspring to noninherited maternal antigens (NIMAs) during pregnancy may have an impact on transplantations performed later in life. Using a mouse model, we recently showed that bone marrow transplantation (BMT) from NIMA-exposed offspring to the mother led to a reduction of graft-versus-host disease (GVHD). Since offspring can also be exposed to NIMAs by breastfeeding after birth, we tested whether breast milk could mediate the tolerogenic NIMA effect. We found that oral exposure to NI-MAs by breastfeeding alone was sufficient to reduce GVHD, and that in utero exposure to NIMAs is required for maximum reduction of GVHD. The tolerogenic milk effects disappeared when donor mice were injected with CD25 monoclonal antibodies during the lactation period, suggesting a CD4 +CD25 + regulatory T cell-dependent mechanism. Our results suggest a previously unknown impact of breastfeeding on the outcome of transplantation.

元の言語英語
ページ(範囲)1829-1833
ページ数5
ジャーナルBlood
113
発行部数8
DOI
出版物ステータス出版済み - 2 19 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Aoyama, K., Koyama, M., Matsuoka, K. I., Hashimoto, D., Ichinohe, T., Harada, M., Akashi, K., Tanimoto, M., & Teshima, T. (2009). Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens. Blood, 113(8), 1829-1833. https://doi.org/10.1182/blood-2008-05-155283