Improved survival of patients with aggressive ATL by increased use of allo-HCT: A prospective observational study

Ayumu Ito, Nobuaki Nakano, Takashi Tanaka, Shigeo Fuji, Junya Makiyama, Yoshitaka Inoue, Ilseung Choi, Hirohisa Nakamae, Koji Nagafuji, Ken Takase, Shinichiro Machida, Tsutomu Takahashi, Yasushi Sawayama, Tomohiko Kamimura, Koji Kato, Toshiro Kawakita, Masao Ogata, Rika Sakai, Souichi Shiratori, Kaoru UchimaruYoshihiro Inamoto, Atae Utsunomiya, Takahiro Fukuda

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)


Aggressive adult T-cell leukemia/lymphoma (ATL) is a hematological malignancy that is difficult to treat with chemotherapy alone, and allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy. We conducted a multicenter, prospective, observational study to clarify the treatment outcomes of aggressive ATL in the current era. Between 2015 and 2018, 113 patients aged 70 years or younger with newly diagnosed aggressive ATL were enrolled. The median age at diagnosis was 61 years. Treatment outcomes were compared with those of 1792 ATL patients diagnosed between 2000 and 2013 in our previous retrospective study. The inclusion criteria were the same in both studies. The prospective cohort demonstrated better overall survival (OS) than the retrospective cohort (2-year OS, 45% vs 29%, respectively; P,.001), with a much higher proportion of patients receiving allo-HCT (80% vs 34%, respectively; P,.001) and a shorter interval from diagnosis to allo-HCT (median, 128 vs 170 days, respectively; P,.001). Among the 90 patients who received allo-HCT (cord blood, n 5 30; HLA-haploidentical related donors, n 5 20; other related donors, n 5 14; other unrelated donors, n 5 26), the 2-year probabilities of OS, nonrelapse mortality (NRM), and disease progression were 44%, 23%, and 46%, respectively. OS and NRM did not differ statistically according to donor type. Our results suggest that increased application of allo-HCT improved the survival of patients with aggressive ATL. The use of cord blood or HLA-haploidentical donors may be feasible for aggressive ATL when HLA-matched related donors are unavailable.

ジャーナルBlood Advances
出版ステータス出版済み - 10月 26 2021

!!!All Science Journal Classification (ASJC) codes

  • 血液学


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