Improvement in Reliability of Probabilistic Test of Significant Differences in GeneChip Experiments

Kyoko Toda, Seiichi Ishida, Kotoko Nakata, Rieko Matsuda, Yukari Shigemoto-Mogami, Shogo Ozawa, Jun Ichi Sawada, Yasuo Ohno, Kazuhide Inoue, Koichi Shudo, Yuzuru Hayashi

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

A probabilistic test (FUMI theory) for GeneChip experiments has been proposed for selecting the genes which show significant differences in the gene expression levels between a single pair of treatment and control. This paper describes that the reliability of the judgment by the FUMI theory can be enhanced, when the selected genes are referred to biomolecular-functional networks of a commercial database. The genes judged as being differently expressed are grouped into a cluster in the biomolecular networks. It is also demonstrated that false positive genes have a trend in the networks to be isolated from each other, and also away from the clustered genes, since the false positive genes are randomly selected.

本文言語英語
ページ(範囲)731-733
ページ数3
ジャーナルanalytical sciences
20
4
DOI
出版ステータス出版済み - 4 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分析化学

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