[Improvement of quantitative accuracy using phase-based respiratory-gated PET/CT in phantom and clinical studies]

Kenta Miwa, Kei Wagatsuma, Takuro Umeda, Noriaki Miyaji, Taisuke Murata, Atsushi Osawa, Tomohiro Takiguchi, Mitsuru Koizumi, Masayuki Sasaki

研究成果: Contribution to journalArticle査読

抄録

OBJECTIVE: The present study aimed at determining the quantitative accuracy of phase-based respiratory-gated PET/CT imaging using phantom and clinical studies.

METHODS: The effects of target size, target-to-background ratio (TBR), and respiratory motion on PET images were estimated using a NEMA body phantom comprising six spheres (diameter 10-37mm) in a solution of F-18 of three different TBRs (4, 6, 8). The phantom was moved in a superior-inferior direction at motion displacements of 0, 10, 20 and 30 mm. Stationary images of the phantom as well as non-gated (3D) and gated (4D) images of the phantom while moving were reconstructed and the recovery coefficient (RC) of individual spheres was calculated from each image. We then determined the RC improvement rate to evaluate improvements conferred by 4D-PET/CT. We retrospectively analyzed data from 14 patients with lung cancer who were examined by 3D- and 4D-PET/CT. Each lesion on the 3D-PET/CT and each of the five phases of the 4D-PET/CT were analyzed.

RESULTS: Larger motion displacement and TBR resulted in increased RC degradation for small spheres. The RC improvement rate showed that 4D acquisition improved the RC of spheres with larger motion displacement exceeding 13 mm in diameter. 4D-PET/CT alone can reduce the effects of motion blurring, but partial volume effects may still be the dominant source of quantitative inaccuracy for small lesions. The trends of phantom and clinical studies for evaluating the improvement rate were similar.

CONCLUSIONS: 4D-PET/CT significantly improved the quantitative accuracy of PET images particularly when larger motion displacement exceeded 17mm in diameter such as in lung cancer.

本文言語英語
ページ(範囲)1235-1242
ページ数8
ジャーナルNihon Hoshasen Gijutsu Gakkai zasshi
70
11
DOI
出版ステータス出版済み - 11 1 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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