In situ electrochemical synthesis of reduced graphene oxide-cobalt oxide nanocomposite modified electrode for selective sensing of depression biomarker in the presence of ascorbic acid and dopamine

Bose Dinesh, Vediyappan Veeramani, Shen Ming Chen, Ramiah Saraswathi

研究成果: Contribution to journalArticle査読

28 被引用数 (Scopus)

抄録

We report the preparation of reduced graphene oxide (RGO)/cobalt oxide (Co3O4) nanocomposite by a simple in situ electrochemical approach and its application towards the trace level selective determination of serotonin in the presence of ascorbic acid and dopamine. Simultaneous electrochemical reduction of graphene oxide (GO) to RGO and electrodeposition of Co3O4 has been achieved onto the glassy carbon electrode (GCE) surface. Raman and XRD studies confirmed the presence of RGO/Co3O4 nanocomposite formation. Scanning electron microscope (SEM) image shows that the presence of Co3O4 nanoflakes over the entire surface of wrinkled thin graphene nanosheets. The electro-oxidation of serotonin has been assessed by cyclic voltammetry and differential pulse voltammetry (DPV) in physiological pH conditions. Interestingly, the oxidation peak current (Ip) of serotonin at GCE/RGO/Co3O4 is 4.1 fold higher than that observed at GCE/RGO and 2.4 fold higher than that observed at GCE/Co3O4 modified electrode. A DPV serotonin sensor with a very low detection limit of 48.7 nM and a high sensitivity of 2.2 mA mM− 1 cm− 2 has been demonstrated using the as prepared GCE/RGO/Co3O4 modified electrode. A comparison of the sensor performance with previous literature clearly shows the superior performance of the fabricated sensor. In addition, the fabricated sensors detect serotonin in vitro directly from diluted blood serum samples.

本文言語英語
ページ(範囲)169-176
ページ数8
ジャーナルJournal of Electroanalytical Chemistry
786
DOI
出版ステータス出版済み - 2 1 2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 化学工学(全般)
  • 電気化学

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