In situ studies on protein adsorption onto a poly(2-methoxyethylacrylate) surface by a quartz crystal microbalance

Masaru Tanaka, Akira Mochizuki, Tadahiro Motomura, Kenichi Shimura, Makoto Onishi, Yoshio Okahata

研究成果: ジャーナルへの寄稿学術誌査読

88 被引用数 (Scopus)

抄録

We have reported that poly(2-methoxyethylacrylate) (PMEA) showed excellent blood compatibility though it had a simple chemical structure, and have been making efforts to clarify the reason for the blood compatibility. It is well-known that the adsorption behavior of the protein affects the compatibility. Therefore, the adsorption behaviors of bovine serum albumin (BSA) and human fibrinogen onto the surfaces of PMEA, poly(2-hydroxyethyl methacrylate) (PHEMA) and polypropylene (PP) were investigated by using a quartz crystal microbalance (QCM), where PHEMA and PP were selected as the representatives of hydrophilic and hydrophobic polymers, respectively. Both proteins were observed to adsorb onto all the polymer surfaces according to Langmuir's adsorption isotherm. The maximum adsorption amounts and the apparent association constants of the proteins for PMEA obtained from the isotherm were lower than those for PHEMA and PP. These results suggest that the interaction between PMEA and the proteins is weaker than the interaction with PP and PHEMA.

本文言語英語
ページ(範囲)145-152
ページ数8
ジャーナルColloids and Surfaces A: Physicochemical and Engineering Aspects
193
1-3
DOI
出版ステータス出版済み - 12月 15 2001
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 表面および界面
  • 物理化学および理論化学
  • コロイド化学および表面化学

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