In vitro effects of l-ascorbic acid (vitamin C) on aryl hydrocarbon hydroxylase activity in hepatic microsomes of mice

Chikako Kiyohara, Minoru Omura, Tomio Hirohata

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

When aromatic hydrocarbon (Ah)-responsive and -non-responsive strains of mice were pretreated with 3-methylcholanthrene (MC) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), vitamin C reduced the microsomal aryl hydrocarbon hydroxylase (AHH) activity. The AHH inhibitors 7,8-benzoflavone (7,8-BF) and 3-methylsulfonyl-3′,4,4′,5-tetrachlorobiphenyl (3-MSF-3′,4,4′,5-tetraCB) showed various inhibitory effects depending upon the types of microsomes, whereas vitamin C exhibited inhibition irrespective of the types of microsomes. 7,8-BF and 3-MSF-3′,4,4′,5-tetraCB as well as vitamin C suppressed the reverse mutation of the Salmonella typhimurium tester strains TA98 and TA100 induced by benzo[a]pyrene.

元の言語英語
ページ(範囲)227-232
ページ数6
ジャーナルMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
251
発行部数2
DOI
出版物ステータス出版済み - 1 1 1991

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Aryl Hydrocarbon Hydroxylases
Microsomes
Ascorbic Acid
Liver
Aromatic Hydrocarbons
Methylcholanthrene
Benzo(a)pyrene
Salmonella typhimurium
Mutation
In Vitro Techniques
alpha-naphthoflavone

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

これを引用

In vitro effects of l-ascorbic acid (vitamin C) on aryl hydrocarbon hydroxylase activity in hepatic microsomes of mice. / Kiyohara, Chikako; Omura, Minoru; Hirohata, Tomio.

:: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 巻 251, 番号 2, 01.01.1991, p. 227-232.

研究成果: ジャーナルへの寄稿記事

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abstract = "When aromatic hydrocarbon (Ah)-responsive and -non-responsive strains of mice were pretreated with 3-methylcholanthrene (MC) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), vitamin C reduced the microsomal aryl hydrocarbon hydroxylase (AHH) activity. The AHH inhibitors 7,8-benzoflavone (7,8-BF) and 3-methylsulfonyl-3′,4,4′,5-tetrachlorobiphenyl (3-MSF-3′,4,4′,5-tetraCB) showed various inhibitory effects depending upon the types of microsomes, whereas vitamin C exhibited inhibition irrespective of the types of microsomes. 7,8-BF and 3-MSF-3′,4,4′,5-tetraCB as well as vitamin C suppressed the reverse mutation of the Salmonella typhimurium tester strains TA98 and TA100 induced by benzo[a]pyrene.",
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