In vitro effects of l-ascorbic acid (vitamin C) on aryl hydrocarbon hydroxylase activity in hepatic microsomes of mice

Chikako Kiyohara, Minoru Omura, Tomio Hirohata

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

When aromatic hydrocarbon (Ah)-responsive and -non-responsive strains of mice were pretreated with 3-methylcholanthrene (MC) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), vitamin C reduced the microsomal aryl hydrocarbon hydroxylase (AHH) activity. The AHH inhibitors 7,8-benzoflavone (7,8-BF) and 3-methylsulfonyl-3′,4,4′,5-tetrachlorobiphenyl (3-MSF-3′,4,4′,5-tetraCB) showed various inhibitory effects depending upon the types of microsomes, whereas vitamin C exhibited inhibition irrespective of the types of microsomes. 7,8-BF and 3-MSF-3′,4,4′,5-tetraCB as well as vitamin C suppressed the reverse mutation of the Salmonella typhimurium tester strains TA98 and TA100 induced by benzo[a]pyrene.

本文言語英語
ページ(範囲)227-232
ページ数6
ジャーナルMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
251
2
DOI
出版ステータス出版済み - 12 1991

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 遺伝学
  • 健康、毒物学および変異誘発

フィンガープリント

「In vitro effects of l-ascorbic acid (vitamin C) on aryl hydrocarbon hydroxylase activity in hepatic microsomes of mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル