抄録
Biochemical circadian oscillation of KaiC phosphorylation, by mixing three Kai proteins and ATP, has been proven to be the central oscillator of the cyanobacterial circadian clock. In vivo, the intracellular levels of KaiB and KaiC oscillate in a circadian fashion. By scrutinizing KaiC phosphorylation rhythm in a wide range of Kai protein concentrations, KaiA and KaiB were found to be "parameter-tuning" and "state-switching" regulators of KaiC phosphorylation rhythm, respectively. Our results also suggest a possible entrainment mechanism of the cellular circadian clock with the circadian variation of intracellular levels of Kai proteins.
本文言語 | 英語 |
---|---|
ページ(範囲) | 898-902 |
ページ数 | 5 |
ジャーナル | FEBS Letters |
巻 | 584 |
号 | 5 |
DOI | |
出版ステータス | 出版済み - 3月 5 2010 |
外部発表 | はい |
!!!All Science Journal Classification (ASJC) codes
- 生物理学
- 構造生物学
- 生化学
- 分子生物学
- 遺伝学
- 細胞生物学