In vitro succinate dehydrogenase chemosensitivity of gastric carcinoma-relationship to DNA content

A. Saito, D. Korenaga, Y. Maehara, H. Baba, T. Okamura, K. Sugimachi

研究成果: ジャーナルへの寄稿学術誌査読

7 被引用数 (Scopus)


Relationships between in vitro chemosensitivity and cell nuclear DNA content were investigated in malignant cells from 41 patients exhibiting advanced gastric carcinoma. The chemosensitivity was evaluated by measuring the succinate dehydrogenase (SD) activity in drug-exposed cancer cells and the DNA content was microspectrophotometrically determined. Following exposure of malignant tissue to carboquone (CQ) and cisplatin (DDP), the mean SD activity in cells displaying a relatively regular DNA distribution (type II) was significantly higher than that in those exhibiting a widely scattered DNA distribution (type IV;P<0.01 in CQ, P<0.05 in DDP). A similar tendency was recognized in cells that were treated with aclacinomycin A (ACR), Adriamycin (ADM), and mitomycin C (MMC). Such a decrease in SD activity in cells exhibiting a type IV pattern was remarkable, especially in cases undifferentiated adenocarcinoma. Mitotic counting analysis revealed a significantly higher value for DNA pattern type IV as compared with the findings for type II (P<0.01). These results demonstrate that gastric carcinoma displaying a high malignant potentiality shows a better response to antitumor drugs. Adjuvant chemotherapy prescribed following drug-sensitivity testing should be effective against such tumors.

ジャーナルCancer chemotherapy and pharmacology
出版ステータス出版済み - 5月 1992

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 毒物学
  • 薬理学
  • 癌研究
  • 薬理学(医学)


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