In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-d-aspartate receptor blockers

Motoomi Nakamura, Shimako Abe, Yoshinobu Goto, Akiko Chishaki, Kouhei Akazawa, Motohiro Kato

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex. In the present study, we examined the roles of N-methyl-d-aspartate (NMDA) receptors in this seizure model. The intraperitoneal administration of the competitive NMDA receptor blocker dl-2-amino-7-phosphonoheptanoic acid (36 and 72 mg/kg) and the non-competitive NMDA receptor blocker MK-801 (1.35 and 2.7 mg/kg), completely prevented the induction of seizure and bradyarrhythmia or sudden death resulting from seizure. Therefore, the white-noise-induced seizures in Mg-deficient rats are linked to increased neuronal excitability via the NMDA receptor.

本文言語英語
ページ(範囲)249-256
ページ数8
ジャーナルEpilepsy Research
17
3
DOI
出版ステータス出版済み - 3月 1994

!!!All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学

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