In Vivo Biocompatibility Evaluation of a New Resilient, Hard-Carbon, Thin-Film Coating for Ventricular Assist Devices

Tohru Takaseya, Hideyuki Fumoto, Akira Shiose, Yoko Arakawa, Santosh Rao, David J. Horvath, Alex L. Massiello, Nicole Mielke, Ji Feng Chen, Qun Zhou, Raymond Dessoffy, Larry Kramer, Stephen Benefit, Leonard A.R. Golding, Kiyotaka Fukamachi

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

The purpose of this study was to evaluate in vivo the biocompatibility of BioMedFlex (BMF), a new resilient, hard-carbon, thin-film coating, as a blood journal bearing material in Cleveland Heart's (Charlotte, NC, USA) continuous-flow right and left ventricular assist devices (RVADs and LVADs). BMF was applied to RVAD rotating assemblies or both rotating and stator assemblies in three chronic bovine studies. In one case, an LVAD with a BMF-coated stator was also implanted. Cases 1 and 3 were electively terminated at 18 and 29 days, respectively, with average measured pump flows of 4.9 L/min (RVAD) in Case 1 and 5.7 L/min (RVAD) plus 5.7 L/min (LVAD) in Case 3. Case 2 was terminated prematurely after 9 days because of sepsis. The sepsis, combined with running the pump at minimum speed (2000 rpm), presented a worst-case biocompatibility challenge. Postexplant evaluation of the blood-contacting journal bearing surfaces showed no biologic deposition in any of the four pumps. Thrombus inside the RVAD inlet cannula in Case 3 is believed to be the origin of a nonadherent thrombus wrapped around one of the primary impeller blades. In conclusion, we demonstrated that BMF coatings can provide good biocompatibility in the journal bearing for ventricular assist devices.

元の言語英語
ページ(範囲)1158-1163
ページ数6
ジャーナルArtificial Organs
34
発行部数12
DOI
出版物ステータス出版済み - 12 1 2010

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Heart-Assist Devices
Journal bearings
Biocompatibility
Carbon
Pumps
Thin films
Coatings
Stators
Sepsis
Thrombosis
Blood
Left ventricular assist devices

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

これを引用

In Vivo Biocompatibility Evaluation of a New Resilient, Hard-Carbon, Thin-Film Coating for Ventricular Assist Devices. / Takaseya, Tohru; Fumoto, Hideyuki; Shiose, Akira; Arakawa, Yoko; Rao, Santosh; Horvath, David J.; Massiello, Alex L.; Mielke, Nicole; Chen, Ji Feng; Zhou, Qun; Dessoffy, Raymond; Kramer, Larry; Benefit, Stephen; Golding, Leonard A.R.; Fukamachi, Kiyotaka.

:: Artificial Organs, 巻 34, 番号 12, 01.12.2010, p. 1158-1163.

研究成果: ジャーナルへの寄稿記事

Takaseya, T, Fumoto, H, Shiose, A, Arakawa, Y, Rao, S, Horvath, DJ, Massiello, AL, Mielke, N, Chen, JF, Zhou, Q, Dessoffy, R, Kramer, L, Benefit, S, Golding, LAR & Fukamachi, K 2010, 'In Vivo Biocompatibility Evaluation of a New Resilient, Hard-Carbon, Thin-Film Coating for Ventricular Assist Devices', Artificial Organs, 巻. 34, 番号 12, pp. 1158-1163. https://doi.org/10.1111/j.1525-1594.2009.00985.x
Takaseya, Tohru ; Fumoto, Hideyuki ; Shiose, Akira ; Arakawa, Yoko ; Rao, Santosh ; Horvath, David J. ; Massiello, Alex L. ; Mielke, Nicole ; Chen, Ji Feng ; Zhou, Qun ; Dessoffy, Raymond ; Kramer, Larry ; Benefit, Stephen ; Golding, Leonard A.R. ; Fukamachi, Kiyotaka. / In Vivo Biocompatibility Evaluation of a New Resilient, Hard-Carbon, Thin-Film Coating for Ventricular Assist Devices. :: Artificial Organs. 2010 ; 巻 34, 番号 12. pp. 1158-1163.
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abstract = "The purpose of this study was to evaluate in vivo the biocompatibility of BioMedFlex (BMF), a new resilient, hard-carbon, thin-film coating, as a blood journal bearing material in Cleveland Heart's (Charlotte, NC, USA) continuous-flow right and left ventricular assist devices (RVADs and LVADs). BMF was applied to RVAD rotating assemblies or both rotating and stator assemblies in three chronic bovine studies. In one case, an LVAD with a BMF-coated stator was also implanted. Cases 1 and 3 were electively terminated at 18 and 29 days, respectively, with average measured pump flows of 4.9 L/min (RVAD) in Case 1 and 5.7 L/min (RVAD) plus 5.7 L/min (LVAD) in Case 3. Case 2 was terminated prematurely after 9 days because of sepsis. The sepsis, combined with running the pump at minimum speed (2000 rpm), presented a worst-case biocompatibility challenge. Postexplant evaluation of the blood-contacting journal bearing surfaces showed no biologic deposition in any of the four pumps. Thrombus inside the RVAD inlet cannula in Case 3 is believed to be the origin of a nonadherent thrombus wrapped around one of the primary impeller blades. In conclusion, we demonstrated that BMF coatings can provide good biocompatibility in the journal bearing for ventricular assist devices.",
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AU - Shiose, Akira

AU - Arakawa, Yoko

AU - Rao, Santosh

AU - Horvath, David J.

AU - Massiello, Alex L.

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AU - Chen, Ji Feng

AU - Zhou, Qun

AU - Dessoffy, Raymond

AU - Kramer, Larry

AU - Benefit, Stephen

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