In vivo-CT system with respiratory and cardiac gating using synchrotron radiation

Toshihiro Sera, Hideo Yokota, Kazuhiro Fujisaki, Kazuaki Fukasaku, Kentaro Uesugi, Naoto Yagi, Ryutaro Himeno

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

1 被引用数 (Scopus)

抄録

The interest in using small animal models of human disease has produced a need to design a CT system at a microscopic level comparable to that achievable in a clinical CT in human. In this study, we developed a high-resolution in vivo-CT system with respiratory and cardiac gating using synchrotron radiation. The system was constructed in BL20B2 at SPring-8. SPring-8 is the third generation synchrotron radiation source in Hyogo, Japan, and prefers much higher flux X-ray than a laboratory X-ray source. Another advantage of synchrotron monochromatic CT is the minimalization of beam hardening effects, which pose serious problems when using white X-rays. Since the X-ray beam from the synchrotron source is parallel, each horizontal line corresponds to a slice position along the rotation axis. Multiple slices are easily obtained in one rotation (3D-CT). For in vivo scanning, the X-ray mechanical shutter and CCD electrical shutter were synchronized with an airway pressure (respiratory) and electrocardiographic (ECG) signal. Synchronization reduced the motion artifacts caused by respiration and heart beats, markedly improving visualization of the edges of the heart, ribs and diaphragm. In particular, small airways (diameter > 300 μm) and cerebral blood vessels were visualized clearly. This system is very useful for evaluating lung physiology and cardiovascular mechanics in vivo.

本文言語英語
ホスト出版物のタイトルMedical Imaging 2007
ホスト出版物のサブタイトルPhysiology, Function, and Structure from Medical Images
PART 1
DOI
出版ステータス出版済み - 10 15 2007
外部発表はい
イベントMedical Imaging 2007: Physiology, Function, and Structure from Medical Images - San Diego, CA, 米国
継続期間: 2 18 20072 20 2007

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
番号PART 1
6511
ISSN(印刷版)1605-7422

その他

その他Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
国/地域米国
CitySan Diego, CA
Period2/18/072/20/07

All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

フィンガープリント

「In vivo-CT system with respiratory and cardiac gating using synchrotron radiation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル