In vivo diagnosis and therapy of human tumors with monoclonal antibodies: Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung

James L. Mulshine, Ingalil Avis, Anthony M. Treston, Philip G. Kasprzyk, Yoichi Nakanishi, Cindy Mobley, Jorge A. Carrasquillo, Steven M. Larson, Bruce Merchant, Frank Cuttitta

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Initial monoclonal antibody therapy trials include an attempt to control malignant proliferation of small cell lung cancer by blocking the autocrine stimulation of gastrin releasing peptide. A critical issue is the adequacy of antibody penetration into the tumor bed to effect immunologic blockade of the mitogenic peptide. The use of an indium-111 antibody chelate which is coadministered with the first therapeutic antibody administration facilitates analysis of the pharmacokinetic dynamics for this trial. If this approach is successful with gastrin releasing peptide, other peptide hormones with autocrine effects could also be targeted. A combination of anti growth factor therapies could lead to successful therapeutic control of this lethal disease.

元の言語英語
ページ(範囲)159-162
ページ数4
ジャーナルInternational Journal of Radiation Applications and Instrumentation.
16
発行部数2
DOI
出版物ステータス出版済み - 1 1 1989
外部発表Yes

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Small Cell Lung Carcinoma
Monoclonal Antibodies
Gastrin-Releasing Peptide
Antibodies
Neoplasms
Indium
Peptide Hormones
Therapeutics
Intercellular Signaling Peptides and Proteins
Pharmacokinetics
Peptides
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

In vivo diagnosis and therapy of human tumors with monoclonal antibodies : Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung. / Mulshine, James L.; Avis, Ingalil; Treston, Anthony M.; Kasprzyk, Philip G.; Nakanishi, Yoichi; Mobley, Cindy; Carrasquillo, Jorge A.; Larson, Steven M.; Merchant, Bruce; Cuttitta, Frank.

:: International Journal of Radiation Applications and Instrumentation., 巻 16, 番号 2, 01.01.1989, p. 159-162.

研究成果: ジャーナルへの寄稿記事

Mulshine, James L. ; Avis, Ingalil ; Treston, Anthony M. ; Kasprzyk, Philip G. ; Nakanishi, Yoichi ; Mobley, Cindy ; Carrasquillo, Jorge A. ; Larson, Steven M. ; Merchant, Bruce ; Cuttitta, Frank. / In vivo diagnosis and therapy of human tumors with monoclonal antibodies : Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung. :: International Journal of Radiation Applications and Instrumentation. 1989 ; 巻 16, 番号 2. pp. 159-162.
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abstract = "Initial monoclonal antibody therapy trials include an attempt to control malignant proliferation of small cell lung cancer by blocking the autocrine stimulation of gastrin releasing peptide. A critical issue is the adequacy of antibody penetration into the tumor bed to effect immunologic blockade of the mitogenic peptide. The use of an indium-111 antibody chelate which is coadministered with the first therapeutic antibody administration facilitates analysis of the pharmacokinetic dynamics for this trial. If this approach is successful with gastrin releasing peptide, other peptide hormones with autocrine effects could also be targeted. A combination of anti growth factor therapies could lead to successful therapeutic control of this lethal disease.",
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AU - Kasprzyk, Philip G.

AU - Nakanishi, Yoichi

AU - Mobley, Cindy

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