In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics

Fuminori Hyodo, Hinako Eto, Tatsuya Naganuma, Norikazu Koyasu, Abdelazim Elsayed Elhelaly, Yoshifumi Noda, Hiroki Kato, Masaharu Murata, Tomohiko Akahoshi, Makoto Hashizume, Hideo Utsumi, Masayuki Matsuo

研究成果: ジャーナルへの寄稿総説査読

抄録

Significance: In vivo molecular and metabolic imaging is an emerging field in biomedical research that aims to perform noninvasive detection of tissue metabolism in disease states and responses to therapeutic agents. The imbalance in tissue oxidation/reduction (Redox) states is related to the onset and progression of several diseases. Tissue redox metabolism provides biomarkers for early diagnosis and drug treatments. Thus, noninvasive imaging of redox metabolism could be a useful, novel diagnostic tool for diagnosis of redox-related disease and drug discovery. Recent Advances: In vivo dynamic nuclear polarization magnetic resonance imaging (DNP-MRI) is a technique that enables the imaging of free radicals in living animals. DNP enhances the MRI signal by irradiating the target tissue or solution with the free radical molecule's electron paramagnetic resonance frequency before executing pulse sequence of the MRI. In vivo DNP-MRI with redox-sensitive nitroxyl radicals as the DNP redox contrast agent enables the imaging of the redox metabolism on various diseases. Moreover, nitroxyl radicals show antioxidant effects that suppress oxidative stress. Critical Issues: To date, considerable progress has been documented preclinically in the development of animal imaging systems. Here, we review redox imaging of in vivo DNP-MRI with a focus on the recent progress of this system and its uses in patients with redox-related diseases. Future Directions: This technique could have broad applications in the study of other redox-related diseases, such as cancer, inflammation, and neurological disorders, and facilitate the evaluation of treatment response as a theranostic tool. Antioxid. Redox Signal. 36, 172-184.

本文言語英語
ページ(範囲)172-184
ページ数13
ジャーナルAntioxidants and Redox Signaling
36
1-3
DOI
出版ステータス出版済み - 1月 1 2022

!!!All Science Journal Classification (ASJC) codes

  • 生理学
  • 生化学
  • 分子生物学
  • 臨床生化学
  • 細胞生物学

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