In vivo gene transfer of soluble TNF-alpha receptor 1 alleviates myocardial infarction.

Masahiro Sugano, Masamichi Koyanagi, Keiko Tsuchida, Tomoji Hata, Naoki Makino

研究成果: ジャーナルへの寄稿学術誌査読

23 被引用数 (Scopus)

抄録

Apoptosis is the major independent form of cardiomyocyte cell death in acute myocardial infarction (AMI). TNF-alpha release early in the course of AMI contributes to myocardial injury, and TNF-alpha induces apoptosis in cardiomyocytes. Soluble TNF-alpha receptor 1 (sTNFR1) is an antagonist to TNF-alpha. However, the effect of sTNFR1 on AMI remains unclear. Here we report that direct injection of an sTNFR1 expression plasmid DNA to the myocardium reduces infarct size in experimental rat AMI. Treatment with sTNFR1 expression plasmid DNA reduced the TNF-alpha bioactivity in the myocardium and the apoptosis of cardiomyocytes. These findings suggest that the anti-TNF-alpha therapy by sTNFR1 can be a new strategy for treatment of AMI.

本文言語英語
ページ(範囲)1421-1422
ページ数2
ジャーナルThe FASEB journal : official publication of the Federation of American Societies for Experimental Biology
16
11
DOI
出版ステータス出版済み - 9月 2002

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 生化学
  • 分子生物学
  • 遺伝学

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