In vivo imaging of oxidative stress in the kidney of diabetic mice and its normalization by angiotensin II type 1 receptor blocker

Toshiyo Sonta, Toyoshi Inoguchi, Shingo Matsumoto, Keiji Yasukawa, Mieko Inuo, Hirotaka Tsubouchi, Noriyuki Sonoda, Kunihisa Kobayashi, Hideo Utsumi, Hajime Nawata

研究成果: ジャーナルへの寄稿学術誌査読

59 被引用数 (Scopus)

抄録

This study was undertaken to evaluate oxidative stress in the kidney of diabetic mice by electron spin resonance (ESR) imaging technique. Oxidative stress in the kidney was evaluated as organ-specific reducing activity with the signal decay rates of carbamoyl-PROXYL probe using ESR imaging. The signal decay rates were significantly faster in corresponding image pixels of the kidneys of streptozotocin-induced diabetic mice than in those of controls. This technique further demonstrated that administration of angiotensin II type 1 receptor blocker (ARB), olmesartan (5 mg/kg), completely restored the signal decay rates in the diabetic kidneys to control values. In conclusion, this study provided for the first time the in vivo evidence for increased oxidative stress in the kidneys of diabetic mice and its normalization by ARB as evaluated by ESR imaging. This technique would be useful as a means of further elucidating the role of oxidative stress in diabetic nephropathy.

本文言語英語
ページ(範囲)415-422
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
330
2
DOI
出版ステータス出版済み - 5月 6 2005
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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