In vivo monitoring of gold nanorods and tissue damage mediated with their photothermal effect

Takuro Niidome, Yasuyuki Akiyama, Kohei Shimoda, Takahito Kawano, Takeshi Mori, Yoshiki Katayama, Yasuro Niidome

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

抄録

Gold nanorods have a strong surface plasmon band at the near infrared region. The absorbed light energy is then converted to heat. Since near infrared light can penetrate deeply into tissue, gold nanorods are expected to be used as a contrast agent for bioimaging using the near infrared light and photosensitizers for photothermal therapy. The surface plasmon bands of intravenously injected the gold nanorods were directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from PEG5,000-modified gold nanorods immediately increased after injection and reached a plateau. The injection of phosphatidylcholine-modified gold nanorods also increased the absorbance at 900 nm, but the absorbance decreased single exponentially with a 1.3-min half-life. To demonstrate photothermal tumor therapy, the PEG-modified gold nanorods were directly injected into subcutaneous tumors in mice, then, near infrared laser light was irradiated to the tumor. After the treatment, significant suppression of tumor growth was observed.

本文言語英語
ホスト出版物のタイトルNanofunctional Materials, Structures, and Devices for Biomedical Applications
ページ73-78
ページ数6
出版ステータス出版済み - 12月 1 2009
イベント2009 MRS Fall Meeting - Boston, MA, 米国
継続期間: 11月 29 200912月 3 2009

出版物シリーズ

名前Materials Research Society Symposium Proceedings
1138
ISSN(印刷版)0272-9172

会議

会議2009 MRS Fall Meeting
国/地域米国
CityBoston, MA
Period11/29/0912/3/09

!!!All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 凝縮系物理学
  • 材料力学
  • 機械工学

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