In vivo monitoring of intravenously injected gold nanorods using near-infrared light

Takuro Niidome, Yasuyuki Akiyama, Kohei Shimoda, Takahito Kawano, Takeshi Mori, Yoshiki Katayama, Yasuro Niidome

研究成果: ジャーナルへの寄稿学術誌査読

52 被引用数 (Scopus)

抄録

bold nanorods showing surface plasmon (SP) bands in the near-IR region are used as bioimaging probes that respond to near-IR light in mice. The SP bands of intravenously injected polyethylene gly col-modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine-modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3-min half-life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.

本文言語英語
ページ(範囲)1001-1007
ページ数7
ジャーナルSmall
4
7
DOI
出版ステータス出版済み - 7月 1 2008

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 生体材料
  • 化学 (全般)
  • 材料科学(全般)

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