In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kotaro Abe, Toyokazu Uwatoku, Fuminori Hyodo, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa, Hideo Utsumi, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抄録

A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

元の言語英語
ページ(範囲)2787-2790
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
14
発行部数11
DOI
出版物ステータス出版済み - 6 7 2004

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Vascular System Injuries
Magnetic resonance imaging
Contrast Media
Rats
Common Carotid Artery
Balloons
Blood vessels
Vascular Diseases
Blood Vessels
Coloring Agents
Swine
Wounds and Injuries
Experiments
EB-DTPA-Gd

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

これを引用

In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent. / Yamamoto, Tatsuhiro; Ikuta, Kenjiro; Oi, Keiji; Abe, Kotaro; Uwatoku, Toyokazu; Hyodo, Fuminori; Murata, Masaharu; Shigetani, Noboru; Yoshimitsu, Kengo; Shimokawa, Hiroaki; Utsumi, Hideo; Katayama, Yoshiki.

:: Bioorganic and Medicinal Chemistry Letters, 巻 14, 番号 11, 07.06.2004, p. 2787-2790.

研究成果: ジャーナルへの寄稿記事

Yamamoto, T, Ikuta, K, Oi, K, Abe, K, Uwatoku, T, Hyodo, F, Murata, M, Shigetani, N, Yoshimitsu, K, Shimokawa, H, Utsumi, H & Katayama, Y 2004, 'In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent', Bioorganic and Medicinal Chemistry Letters, 巻. 14, 番号 11, pp. 2787-2790. https://doi.org/10.1016/j.bmcl.2004.03.066
Yamamoto, Tatsuhiro ; Ikuta, Kenjiro ; Oi, Keiji ; Abe, Kotaro ; Uwatoku, Toyokazu ; Hyodo, Fuminori ; Murata, Masaharu ; Shigetani, Noboru ; Yoshimitsu, Kengo ; Shimokawa, Hiroaki ; Utsumi, Hideo ; Katayama, Yoshiki. / In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent. :: Bioorganic and Medicinal Chemistry Letters. 2004 ; 巻 14, 番号 11. pp. 2787-2790.
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