In vivo performance of biodegradable calcium phosphate glass ceramics using the rabbit model

Histological and SEM observation

A. G. Dias, M. A. Lopes, J. D. Santos, A. Afonso, Kanji Tsuru, A. Osaka, S. Hayakawa, S. Takashima, Y. Kurabayashi

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

抄録

Two MK5 (45CaO-45P2O5-5MGO-5K2O, in mol% and MT13 (45CaO-37P2O5-5MgO-13TiO 2, in mol%) glasses are prepared in the meta- and pyrophosphate regions and crystallized to obtain MK5B and MT13B, respectively. MK5B was obtained by controlled crystallization, and MT13B by powder sintering. As a result of these heat treatment processes, the crystalline phases precipitated in the glassy matrix are KCa(PO3)3, β-Ca(PO3)2, β-Ca2P2O7 and Ca4P6O19 phases for MK5B and CaTi4(PO4)6, TiP2O7, α- and β-Ca2P2O7 phases for MT13B. To assess the in vivo biological behavior of these glass ceramics, a mixed granulometry in the range 250-355 μm and 355-425 μm with a ratio of 1/1 was implanted for 2, 4, and 12 weeks in the tibiae of Japanese white rabbits. The results showed that the in vivo behavior was strongly affected by their solubility. All implanted materials, MK5B and MT13B, and β-tricalcium phosphate (β-TCP) as control material, showed signs of degradation in vivo. However, the levels of degradation were quite different throughout the implantation periods. The highest degradation was observed for MK5B glass ceramic and the lowest for MT13B with β-TCP in-between. All implanted materials allow for new bone formation in the bone defect area. At the longest implantation period (12 weeks), the MT13B and β-TCP materials were almost completely surrounded by new bone tissue, whereas MK5B showed some unfilled spaces. This behavior is discussed in terms of the high degradation observed in previous studies.

元の言語英語
ページ(範囲)253-266
ページ数14
ジャーナルJournal of Biomaterials Applications
20
発行部数3
DOI
出版物ステータス出版済み - 1 1 2006

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Calcium phosphate
Glass ceramics
Degradation
Bone
Scanning electron microscopy
Crystallization
Ion implantation
Powders
Phosphates
Sintering
Solubility
Heat treatment
Tissue
Crystalline materials
Glass
Defects
calcium phosphate

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

これを引用

In vivo performance of biodegradable calcium phosphate glass ceramics using the rabbit model : Histological and SEM observation. / Dias, A. G.; Lopes, M. A.; Santos, J. D.; Afonso, A.; Tsuru, Kanji; Osaka, A.; Hayakawa, S.; Takashima, S.; Kurabayashi, Y.

:: Journal of Biomaterials Applications, 巻 20, 番号 3, 01.01.2006, p. 253-266.

研究成果: ジャーナルへの寄稿記事

Dias, AG, Lopes, MA, Santos, JD, Afonso, A, Tsuru, K, Osaka, A, Hayakawa, S, Takashima, S & Kurabayashi, Y 2006, 'In vivo performance of biodegradable calcium phosphate glass ceramics using the rabbit model: Histological and SEM observation', Journal of Biomaterials Applications, 巻. 20, 番号 3, pp. 253-266. https://doi.org/10.1177/0885328206052466
Dias, A. G. ; Lopes, M. A. ; Santos, J. D. ; Afonso, A. ; Tsuru, Kanji ; Osaka, A. ; Hayakawa, S. ; Takashima, S. ; Kurabayashi, Y. / In vivo performance of biodegradable calcium phosphate glass ceramics using the rabbit model : Histological and SEM observation. :: Journal of Biomaterials Applications. 2006 ; 巻 20, 番号 3. pp. 253-266.
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abstract = "Two MK5 (45CaO-45P2O5-5MGO-5K2O, in mol{\%} and MT13 (45CaO-37P2O5-5MgO-13TiO 2, in mol{\%}) glasses are prepared in the meta- and pyrophosphate regions and crystallized to obtain MK5B and MT13B, respectively. MK5B was obtained by controlled crystallization, and MT13B by powder sintering. As a result of these heat treatment processes, the crystalline phases precipitated in the glassy matrix are KCa(PO3)3, β-Ca(PO3)2, β-Ca2P2O7 and Ca4P6O19 phases for MK5B and CaTi4(PO4)6, TiP2O7, α- and β-Ca2P2O7 phases for MT13B. To assess the in vivo biological behavior of these glass ceramics, a mixed granulometry in the range 250-355 μm and 355-425 μm with a ratio of 1/1 was implanted for 2, 4, and 12 weeks in the tibiae of Japanese white rabbits. The results showed that the in vivo behavior was strongly affected by their solubility. All implanted materials, MK5B and MT13B, and β-tricalcium phosphate (β-TCP) as control material, showed signs of degradation in vivo. However, the levels of degradation were quite different throughout the implantation periods. The highest degradation was observed for MK5B glass ceramic and the lowest for MT13B with β-TCP in-between. All implanted materials allow for new bone formation in the bone defect area. At the longest implantation period (12 weeks), the MT13B and β-TCP materials were almost completely surrounded by new bone tissue, whereas MK5B showed some unfilled spaces. This behavior is discussed in terms of the high degradation observed in previous studies.",
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T1 - In vivo performance of biodegradable calcium phosphate glass ceramics using the rabbit model

T2 - Histological and SEM observation

AU - Dias, A. G.

AU - Lopes, M. A.

AU - Santos, J. D.

AU - Afonso, A.

AU - Tsuru, Kanji

AU - Osaka, A.

AU - Hayakawa, S.

AU - Takashima, S.

AU - Kurabayashi, Y.

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