In vivo spectral-spatial imaging for oxygen mapping using single-point, time-domain electron paramagnetic resonance

Sankaran Subramanian, Calvin A. Johnson, Nallathamby Devasahayam, Ken Ichiro Matsumoto, Fuminori Hyodo, John Cook, Murali C. Krishna

    研究成果: 書籍/レポート タイプへの寄稿会議への寄与

    2 被引用数 (Scopus)

    抄録

    Electron Paramagnetic Resonance (EPR) is a spectroscopic technique that detects and characterizes molecules with unpaired electrons (i.e., free radicals). Although it is closely related to nuclear magnetic resonance (NMR) spectroscopy, EPR is still under development as an imaging modality. Unlike other imaging modalities, EPR is able to take direct measurements of tissue oxygen concentration in a manner that is not dependent on complex biological processes such as ligand binding specificity or tracer metabolism. We describe the use of single-point imaging (SPI) in radiofrequency, Fourier-transform EPR. We present the techniques for performing oxygen imaging using EPR with phantoms and in vivo. We present results from a study in which the two mouse legs (one normal and the other with tumor) were imaged over time as the mouse breathed alternately air, carbogen (95% O 2, 5% CO 2), and then air again. The reconstructed images demonstrate that the SPI EPR imaging technique readily distinguishes between the normal and tumor legs and can track the changes in tissue oxygen concentration in response to percentage of oxygen in breathing gas.

    本文言語英語
    ホスト出版物のタイトル2006 3rd IEEE International Symposium on Biomedical Imaging
    ホスト出版物のサブタイトルFrom Nano to Macro - Proceedings
    ページ1096-1099
    ページ数4
    出版ステータス出版済み - 11月 17 2006
    イベント2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, 米国
    継続期間: 4月 6 20064月 9 2006

    出版物シリーズ

    名前2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
    2006

    その他

    その他2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
    国/地域米国
    CityArlington, VA
    Period4/6/064/9/06

    !!!All Science Journal Classification (ASJC) codes

    • 工学(全般)

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