Inactivating potassium currents in apical and basal turn inner hair cells from guinea-pig cochlea

Takashi Kimitsuki, Ayako Nawate, Yasuhiro Kakazu, Nozomu Matsumoto, Kazutaka Takaiwa, Noritaka Komune, Teppei Noda, Shizuo Komune

研究成果: Contribution to journalArticle査読

抄録

Tetraethylammonium (TEA)-sensitive potassium currents in the cochlear inner hair cells (IHCs) possess the kinetics of fast inactivation. IHCs of guinea-pigs were separately isolated from the apical and basal turns and the tonotopic gradient of inactivation kinetics was investigated. TEA-sensitive potassium currents showed voltage-dependent time constant of the inactivation phase both in apical and basal IHCs, however, the degree of inactivation (compared to the ratio between the steady-state current and initial peak current) was voltage-independent. Inactivation time constant was faster in basal IHCs than in apical IHCs and the degree of inactivation was greater in basal IHCs than in apical IHCs, suggesting that inactivation was more predominant in basal IHCs than in apical IHCs.

本文言語英語
ページ(範囲)68-72
ページ数5
ジャーナルBrain Research
1228
DOI
出版ステータス出版済み - 9 4 2008

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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