TY - JOUR
T1 - Incorporation of Ca2+ ions in gelatin-siloxane hybrids through a sol-gel process
AU - Ren, L.
AU - Tsuru, Kanji
AU - Hayakawa, S.
AU - Osaka, A.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Several gelatin-siloxane hybrids incorporating Ca2+ ions were synthesized through a sol-gel process starting with gelatin, 3-(glycidoxypropyl) trimethoxysilane (GPSM), and Ca(NO3)2. Amino acid analysis, 29Si NMR spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, and dynamic mechanical thermal analysis were used to assess the hybrid structure. It has been indicated that the grafting degree of epoxy groups of GPSM to gelatin and the extent of polymerization of methoxysilane end groups of GPSM strongly depended on the fraction of GPSM (fG) in the hybrids, but not on incorporation of Ca2+ ions. Hence, the hybrids with the same fG value, independent of incorporation of Ca2+ ions, had a similar cross-link density. However, the glass transition temperature (Tg) and storage modulus (E′) around Tg decreased with incorporation of Ca2+ ions. Through the deconvolution of amide I bands of FT-IR spectra, flexibility may be interpreted by that the percentage of gelatin having a random structure increased with incorporation of Ca2+ ions. The Ca2+-containing hybrids can spontaneously deposit apatite when they were soaked in a simulated body fluid of the Kokubo recipe, showing their bioactivity.
AB - Several gelatin-siloxane hybrids incorporating Ca2+ ions were synthesized through a sol-gel process starting with gelatin, 3-(glycidoxypropyl) trimethoxysilane (GPSM), and Ca(NO3)2. Amino acid analysis, 29Si NMR spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, and dynamic mechanical thermal analysis were used to assess the hybrid structure. It has been indicated that the grafting degree of epoxy groups of GPSM to gelatin and the extent of polymerization of methoxysilane end groups of GPSM strongly depended on the fraction of GPSM (fG) in the hybrids, but not on incorporation of Ca2+ ions. Hence, the hybrids with the same fG value, independent of incorporation of Ca2+ ions, had a similar cross-link density. However, the glass transition temperature (Tg) and storage modulus (E′) around Tg decreased with incorporation of Ca2+ ions. Through the deconvolution of amide I bands of FT-IR spectra, flexibility may be interpreted by that the percentage of gelatin having a random structure increased with incorporation of Ca2+ ions. The Ca2+-containing hybrids can spontaneously deposit apatite when they were soaked in a simulated body fluid of the Kokubo recipe, showing their bioactivity.
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U2 - 10.2109/jcersj.109.1269_406
DO - 10.2109/jcersj.109.1269_406
M3 - Article
AN - SCOPUS:0035331248
VL - 109
SP - 406
EP - 411
JO - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
JF - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
SN - 1882-0743
IS - 1269
ER -